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Seroprevalence of anti-Hp and anti-cagA antibodies among healthy persons in Golestan province, northeast of Iran (2010)

Kebria, F.G. and Bagheri, H. and Semnani, S. and Ghaemi, E. (2011) Seroprevalence of anti-Hp and anti-cagA antibodies among healthy persons in Golestan province, northeast of Iran (2010). Caspian Journal of Internal Medicine, 2 (3). pp. 256-260. ISSN 20086164 (ISSN)

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Abstract

Background: The major cause of peptic ulcer disease is helicobacter pylori (Hp), and it is also implicated in the pathogenesis of adenocarcinoma of the distal stomach and gastric lymphoma. The incidence of peptic ulcer disease, atrophic gastritis, and gastric adenocarcinoma are more common in people infected of cagA positive strains of Hp. The aim of this study was to determine the prevalence of the anti-Hp and anti-cagA antibodies among healthy persons in Golestan province-North of Iran. Methods: The blood samples of 1028 healthy people were collected all over Golestan province by cluster sampling. A demographic questionnaire was completed and body mass index (BMI) was calculated for each case. Hp-IgG (Pishtaz teb Co. Iran) and anti- cagA (DIA.PRO Italy) titer were evaluated by Elisa method. Data were collected and analyzed. Results: Six hundred-eighty three individuals (66.4%) were positive for Hp and 395 (57.8%) of them were cagA positive. Hp positive cases were (66.3%) and (66.6%) in male and female, respectively. Prevalence of cagA was 56.3% and 58.9%, respectively. The most seropositivity of Helicobacter Pylori (75.4%) was in 55-64 years old (p<0.001). Prevalence of cagA (63.4%) was more in age between 15-24 years. Conclusion: Prevalence of anti-Hp antibody and strains of cagA seropositive in healthy persons of this province of Iran were relatively high. Preventive protocol for reducing of the infection is recommended.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Caspian J. Int. Med. [Field not mapped to EPrints] AD - Gastroenterology and Hepatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Young Researchers Club, Islamic Azad University, Gorgan Branch, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Antibody, CagA, Helicobacter pylori, Prevalence, bacterium antibody, cytotoxin associated gene A antibody, Helicobacter pylori antibody, unclassified drug, adolescent, adult, age distribution, aged, antibody titer, article, child, enzyme linked immunosorbent assay, ethnicity, female, Helicobacter infection, human, infant, Iran, major clinical study, male, preschool child, questionnaire, seasonal variation, seroprevalence, sex difference, urban rural difference
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:22
Last Modified: 16 May 2015 07:06
URI: http://eprints.goums.ac.ir/id/eprint/2123

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