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One-year prognosis of patients with normal myocardial perfusion imaging using technitium-99m sestamibi in suspected coronary artery disease: A single-center experience of 1,047 patients

Raziei, G. and Tavakoli, A. and Asl, S.S. and Amoiei, M. and Javadi, H. and Assadi, M. (2011) One-year prognosis of patients with normal myocardial perfusion imaging using technitium-99m sestamibi in suspected coronary artery disease: A single-center experience of 1,047 patients. Perfusion, 26 (4). pp. 309-314. ISSN 02676591 (ISSN)

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Abstract

Introduction: The aim of the present study was to evaluate the clinical outcome of a normal stress technetium-99m (99mTc)-Sestamibi single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with different probabilities of coronary artery disease (CAD). Material and Methods: A total of 1,047 subjects with a normal 99mTc-MIBI SPECT were followed up for one year and hard and soft cardiac events were assessed. Hard cardiac events were defined as cardiac death or non-fatal myocardial infarction (MI). Soft cardiac events included the patient's development of recurrent chest pain requiring coronary revascularization or significant stenosis in coronary arteries on angiography. Results: Overall, 1,047 patients (248 men and 799 women; mean age: 60.07 ± 12.31, range 29-92) were enrolled. Three hard cardiac events occurred in the groups; two had cardiac arrest and one non-fatal MI. As a result, the annualized hard cardiac event rate was 0.28%, the annualized cardiac mortality rate was 0.19%, and the rate of overall annualized cardiac events was 1.25%. Furthermore, there was a significant difference in cardiac events among patients with various pretest likelihoods of CAD (p value=0.04). Conclusion: Our data confirmed that patients with a normal 99mTc-Sestamibi myocardial SPECT are associated with a very low incidence of cardiovascular events. © The Author(s) 2011.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Perfusion [Field not mapped to EPrints] C2 - 21508085 [Field not mapped to EPrints] AD - Department of Nuclear Medicine, Milad Hospital, Tehran, Iran [Field not mapped to EPrints] AD - Department of Nuclear Medicine, Shohada-e Tajrish Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 3631, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cardiac event, Coronary artery disease (CAD), Normal myocardial perfusion imaging (MPI), Technetium 99m-Sestamibi SPECT, dipyridamole, dobutamine, methoxy isobutyl isonitrile technetium tc 99m, adult, aged, angiocardiography, article, cardiac patient, coronary artery disease, female, heart arrest, heart catheterization, heart death, heart infarction, heart muscle revascularization, human, major clinical study, male, mortality, myocardial perfusion imaging, pharmacologic stress testing, priority journal, prognosis, single photon emission computer tomography, treadmill exercise, Aged, Coronary Angiography, Coronary Artery Disease, Death, Exercise Test, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, Radiopharmaceuticals, Technetium Tc 99m Sestamibi, Time Factors, Tomography, Emission-Computed, Single-Photon
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 06:21
Last Modified: 16 May 2015 14:50
URI: http://eprints.goums.ac.ir/id/eprint/2114

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