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Efficacy of flour fortification with folic acid in women of childbearing age in Iran

Abdollahi, Z. and Elmadfa, I. and Djazayery, A. and Golalipour, M.J. and Sadighi, J. and Salehi, F. and Sadeghian Sharif, S. (2011) Efficacy of flour fortification with folic acid in women of childbearing age in Iran. Annals of Nutrition and Metabolism, 58 (3). pp. 188-196. ISSN 02506807 (ISSN)

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Abstract

Background: Flour fortification with folic acid is one of the main strategies for improving folate status in women of childbearing age. No interventional trial on the efficacy of folic acid fortification has been conducted so far in Iran. Objectives: To study the effects of flour fortification with folic acid on any reduction in neural tube defects (NTDs) and folate status of women of childbearing age. Methods: In a longitudinal hospital-based study, 13,361 postpartum women were studied after admission for childbirth before and after fortification. In addition, two cross-sectional surveys were conducted before (2006) and after flour fortification (2008). The cluster sampling method was used and 580 women, 15-49 years old, were studied as a representative sample of Golestan province in the north of Iran. Fasting blood samples were collected to measure serum vitamin B 12, folate and plasma homocysteine. Sociodemographic data, health characteristics and dietary intake were determined. Results: The mean daily intakes of folate from natural food before and after flour fortification were 198.3 and 200.8 μg/day, respectively. The total folate intake increased significantly from 198.3 to 413.7 μg/day after fortification (p < 0.001). Folate intake increased by an average of 226 μg/day from fortified bread. The mean serum folate level increased from 13.6 to 18.1 nmol/l; folate deficiency decreased from 14.3 to 2.3% (p < 0.001). The incidence rate of NTDs declined by 31% (p < 0.01) in the post-fortification period (2.19 per 1,000 births; December 2007 to December 2008) compared to the pre-fortification period (3.16 per 1,000 births; September 2006 to July 2007). Conclusions: Implementation of mandatory flour fortification with folic acid can lead to a significant increase in serum folate and a significant decrease in NTDs. Copyright © 2011 S. Karger AG, Basel.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Ann. Nutr. Metab. [Field not mapped to EPrints] C2 - 21757892 [Field not mapped to EPrints] AD - Nutrition Department, Ministry of Health and Medical Education, Iran [Field not mapped to EPrints] AD - Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Science, Iran [Field not mapped to EPrints] AD - Institute for Health Sciences Research, Academic Center for Education, Culture and Research, Iran [Field not mapped to EPrints] AD - Endocrine Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran [Field not mapped to EPrints] AD - Gorgan Congenital Malformations Research Center, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, AT-1090 Vienna, Austria [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Flour fortification, Iran, Mandatory, Neural tube defects, Women, childbearing age, cyanocobalamin, folic acid, homocysteine, adolescent, adult, article, blood sampling, dietary intake, female, flour, folic acid deficiency, human, human experiment, incidence, Iran, longitudinal study, neural tube defect, normal human, nutritional status, priority journal, puerperium, vitamin blood level, Adolescent, Adult, Bread, Cross-Sectional Studies, Female, Flour, Folic Acid, Folic Acid Deficiency, Food, Fortified, Homocysteine, Humans, Iran, Longitudinal Studies, Middle Aged, Neural Tube Defects, Nutritional Status, Socioeconomic Factors, Vitamin B 12, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 08:56
Last Modified: 13 May 2015 09:01
URI: http://eprints.goums.ac.ir/id/eprint/2109

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