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Diagnostic value of 99mTc-ubiquicidin scintigraphy for osteomyelitis and comparisons with 99mTc-methylene diphosphonate scintigraphy and magnetic resonance imaging

Assadi, M. and Vahdat, K. and Nabipour, I. and Sehhat, M.R. and Hadavand, F. and Javadi, H. and Tavakoli, A. and Saberifard, J. and Kalantarhormozi, M.R. and Zakani, A. and Eftekhari, M. (2011) Diagnostic value of 99mTc-ubiquicidin scintigraphy for osteomyelitis and comparisons with 99mTc-methylene diphosphonate scintigraphy and magnetic resonance imaging. Nuclear Medicine Communications, 32 (8). pp. 716-723. ISSN 01433636 (ISSN)

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Abstract

Objective: The discrimination of bacterial infections from sterile inflammatory processes is of great importance in the management of inflammation. Currently available techniques cannot decisively address this issue. In this respect, antimicrobial peptide Tc-ubiquicidin (UBI) 29-41 scans have been showing interesting results. The aim of this study was to determine the accuracy of Tc-UBI scan in the detection of osteomyelitis and to compare it with Tc-methylene diphosphonate scan and magnetic resonance imaging (MRI). Methods: Twenty patients (mean age=48.90 years) with suspected osteomyelitis were included in this study. After evaluation of each patient through history taking, physical examination, appropriate laboratory tests, and other processes including bone probing, wound culture, and plain film radiography, MRIs, Tc-UBI scans, and Tc-methylene diphosphonate scans were performed. For quantitative analysis, the mean count of abnormal-to-normal (A/N) region was calculated for images acquired at 15, 30, 45, 60, 120, and 240 min to obtain the most favorable time for imaging. Results: In total, osteomyelitis was detected in the Tc-UBI scans of 17 patients, indicating 100% accuracy, compared with an accuracy of 90% for osteomyelitis detected in three-phase bone scans. The maximum mean A/N was observed at 15 min after intravenous injection (median: 1.91; interquartile range: 1.54-2.94). MRI was performed in 12 cases only with 75% accuracy. In addition, the A/N ratios for the Tc-UBI scans were not significantly different between patients with or without Staphylococcus aureus growth on wound cultures. Conclusion: For fast imaging with high accuracy, Tc-UBI 29-41 is a suitable choice for the detection of osteomyelitis. © 2011 Wolters Kluwer Health | Lippincott Williams and Wilkins.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Nucl. Med. Commun. [Field not mapped to EPrints] C2 - 21642882 [Field not mapped to EPrints] AD - Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 3631, Iran [Field not mapped to EPrints] AD - Department of Orthopedic Surgery, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran [Field not mapped to EPrints] AD - Departments of Infectious Diseases, Bushehr University of Medical Sciences, Bushehr, Iran [Field not mapped to EPrints] AD - Endocrine and Metabolic Diseases, Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GUOMS), Gorgan, Iran [Field not mapped to EPrints] AD - Department of Nuclear Medicine, Imam Khomeini (Valiasr) Hospital, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: 99mTc-methylene diphosphonate scan, 99mTc-ubiquicidin scan, antimicrobial peptides, infection, magnetic resonance imaging, osteomyelitis, medronate technetium tc 99m, radiopharmaceutical agent, ubiquicidin tc 99m, unclassified drug, diagnostic agent, medronate technetium tc 99m, peptide fragment, technetium 99m ubiquicidin(29 41), technetium 99m ubiquicidin(29-41), technetium complex, absence of side effects, adult, article, bone scintiscanning, clinical article, controlled study, diagnostic accuracy, diagnostic test accuracy study, female, gold standard, Gram negative infection, human, image analysis, intermethod comparison, male, nuclear magnetic resonance imaging, osteomyelitis, scintigraphy, sensitivity and specificity, aged, clinical trial, comparative study, feasibility study, middle aged, nuclear magnetic resonance imaging, osteomyelitis, scintiscanning, Adult, Aged, Feasibility Studies, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organotechnetium Compounds, Osteomyelitis, Peptide Fragments, Sensitivity and Specificity, Technetium Tc 99m Medronate, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 06:02
Last Modified: 13 May 2015 10:03
URI: http://eprints.goums.ac.ir/id/eprint/2108

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