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Role of 99mTc-ubiquicidin 29-41 scintigraphy to monitor antibiotic therapy in patients with orthopedic infection: A preliminary study

Nazari, B. and Azizmohammadi, Z. and Rajaei, M. and Karami, M. and Javadi, H. and Assadi, M. and Asli, I.N. (2011) Role of 99mTc-ubiquicidin 29-41 scintigraphy to monitor antibiotic therapy in patients with orthopedic infection: A preliminary study. Nuclear Medicine Communications, 32 (8). pp. 745-751. ISSN 01433636 (ISSN)

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Abstract

Introduction: Ubiquicidin (UBI) 29-41 is a cationic synthetic antimicrobial peptide fragment that binds preferentially with anionic microbial cell membranes at the site of infection. This study evaluated the potential ability of Tc-UBI 29-41 to assess response to antibiotic therapy in orthopedic infection. Methods: A total of 12 patients, 10 men and two women (mean age, 41.6 years; range, 23-75 years), with suspected orthopedic infection (bone, soft tissue, or prosthesis) and positive Tc-UBI scan for infection were included in the study. One day after the Tc-UBI scan, a bone scan was performed as well. After this evaluation, eight of the nine treated cases responded to the treatment. Then, one nonresponder patient and two nontreated patients of three cases underwent antibiotic therapy and were evaluated again 10-14 days later. After this, one of the two patients not treated the first time responded to therapy and two patients did not. Moreover, one patient refused to undergo therapy both the first and second time. Thus, 11 treated cases were analyzed in this study and divided in two groups: (a) nine treated responders and (b) two treated nonresponders. In all patients, erythrocyte sedimentation rate and C-reactive protein were measured and also wound cultures were assessed. Results: Quantitative analysis of erythrocyte sedimentation rate, C-reactive protein, and bone scan before and after the 10-14-day interval showed no significant change in either group, but a quantitative Tc-UBI scan at 30, 60, and 120 min after tracer injection indicated significant reduction in radiotracer uptake after the 10-14-day interval compared with the Tc-UBI scan before this interval in the responder group, and no significant change in the nonresponder group. Conclusion: The Tc-UBI scan can determine response to antibiotic therapy in orthopedic infection in humans. © 2011 Wolters Kluwer Health | Lippincott Williams and Wilkins.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Nucl. Med. Commun. [Field not mapped to EPrints] AD - Departments of Nuclear Medicine, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Orthopedic Surgery, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 3631, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: 99mTc-methylene diphosphonate scan, 99mTc-ubiquicidin scan, antimicrobial peptides, orthopedic infection, antibiotic agent, C reactive protein, medronate technetium tc 99m, radiopharmaceutical agent, ubiquicidin 29-41 tc 99m, unclassified drug, antiinfective agent, diagnostic agent, peptide fragment, technetium 99m ubiquicidin(29 41), technetium 99m ubiquicidin(29-41), technetium complex, absence of side effects, adult, aged, antibiotic therapy, article, bone infection, bone scintiscanning, clinical article, clinical evaluation, drug uptake, erythrocyte sedimentation rate, female, human, male, feasibility study, infection, middle aged, orthopedics, retrospective study, scintiscanning, treatment outcome, Adult, Aged, Anti-Bacterial Agents, Feasibility Studies, Female, Humans, Infection, Male, Middle Aged, Organotechnetium Compounds, Orthopedics, Peptide Fragments, Retrospective Studies, Treatment Outcome, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 06:01
Last Modified: 23 May 2015 08:44
URI: http://eprints.goums.ac.ir/id/eprint/2107

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