Golestan University of Medical Sciences Repository

Protective effect of Urtica dioica L. (Urticaceae) on morphometric and morphologic alterations of seminiferous tubules in STZ diabetic rats

Golalipour, M.J. and Balajadeh, B.K. and Ghafari, S. and Azarhosh, R. and Khori, V. (2011) Protective effect of Urtica dioica L. (Urticaceae) on morphometric and morphologic alterations of seminiferous tubules in STZ diabetic rats. Iranian Journal of Basic Medical Sciences, 14 (5). pp. 472-477. ISSN 20083866 (ISSN)

[img]
Preview
PDF - Published Version
Download (89kB) | Preview

Abstract

Objective(s): Urtica dioica L. has been known as a medicinal plant in the world. This study was conducted to determine the effects of the hydroalcoholic extract of Urtica dioica leaves on seminiferous tubules of diabetic rats. Materials and Methods: Animals were allocated to control, diabetic and protective groups. Treated animals received extract of U. dioica (100 mg/ kg/ day) IP for the first 5 days and STZ injection on the 6th day. After 5 weeks, testes removed and stained with H&E technique. Results: Tubular cell disintegration, sertoli and spermatogonia cell vacuolization, and decrease in sperm concentration observed in diabetic in comparison with control and protective groups. External seminiferous tubular diameter and seminiferous epithelial height significantly reduced (P< 0.05) in diabetic compared with controls, and these parameters increased (P< 0.05) in the treated compared with diabetics. Conclusion: Hydroalcoholic extract of U. dioica, before induction of diabetes; has protective role on seminiferous tubules alterations.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Iran. J. Basic Med. Sci. [Field not mapped to EPrints] AD - Department of Anatomy (Embryology and Histology), Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Pathology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Pharmacology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Diabet mellitus, Morphometry, Rats, Seminiferous tubules, Testis, Urtica dioica, streptozocin, Urtica dioica extract, animal cell, animal experiment, animal model, animal tissue, article, cell vacuole, controlled study, drug effect, kidney tubule cell, male, morphology, morphometrics, nonhuman, rat, seminiferous tubule, Sertoli cell, spermatogonium, staining, streptozocin diabetes, testis, Urtica dioica, Animalia, Rattus, Urtica dioica, Urticaceae
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:43
Last Modified: 14 May 2015 04:25
URI: http://eprints.goums.ac.ir/id/eprint/2097

Actions (login required)

View Item View Item