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Dynamic age-related changes of extracellular field potential of isolated AV-node of rabbit

Khori, V. and Alizadeh, A.M. and Niknam, M. and Moheimani, H.R. and Yazdi, H.R. and Pourabouk, M. and Badaghabadi, F. and Changizi, S. and Rajaei, M. and Nayebpour, M. (2011) Dynamic age-related changes of extracellular field potential of isolated AV-node of rabbit. Physiology and Pharmacology, 15 (2). pp. 173-181. ISSN 17350581 (ISSN)

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Abstract

Introduction: Developmental changes in atrioventricular nodal conduction time and refractoriness have been shown in several studies. Prevalence of atrioventricular nodal reentrant tachycardia (AVNRT) is clearly age-dependent. The purpose of this study was to determine developmental changes of basic and frequency-dependent electrophysiological properties of the atrioventricular node (AV-node) in neonatal and adult rabbits. Methods: In this study, the effects of increasing age on the basic and rate-dependent properties of isolated perfused AV-node were analyzed in neonatal (2-week-old) and adult (12-week-old) New Zealand rabbits. Specific stimulation protocols of recovery, facilitation and fatigue were separately applied in each group (n=7). Unipolar extracellular field potential was recorded by a silver electrode (100 μM). Results: The results showed that the basic nodal properties (ERP, FRP, WBCL and AHmax) were significantly shorter in neonates compared to the adult group. The magnitude of fatigue was also decreased in the neonatal group compared to control (18.9 ±3.3 vs. 11.1 ± 1.2 msec). Time constant of recovery of the adult group was significantly higher than the neonatal group (P<0.05). Conclusion: The results of this study showed that nodal basic and frequency-dependent properties are age-related and different developmental changes of slow and fast pathways are responsible for this behavior and may reveal the grater susceptibility of AVNRT in young adults compared to infants.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Physiol. Pharmacol. [Field not mapped to EPrints] AD - Golestan Cardiovascular Research Center, Faculty of medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Dept. Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Age, AV node, Electrophysiology, Frequency-dependent properties, Recovery, aging, animal experiment, animal model, animal tissue, article, cell membrane potential, controlled study, electrode, fatigue, heart atrioventricular node, heart electrophysiology, newborn, nonhuman, rabbit, adult, age, Article, electric potential, electrical potential parameters, facilitation, heart electrophysiology, heart muscle refractory period, maximal atrio his conduction interval, Wenchebach Cycle Length
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:54
Last Modified: 17 Jan 2017 08:34
URI: http://eprints.goums.ac.ir/id/eprint/2095

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