Golestan University of Medical Sciences Repository

Effect of Urtica dioica L. (Urticaceae) on testicular tissue in STZ-induced diabetic rat

Ghafari, S. and Kabiri Balajadeh, B. and Golalipour, M.J. (2011) Effect of Urtica dioica L. (Urticaceae) on testicular tissue in STZ-induced diabetic rat. Pakistan Journal of Biological Sciences, 14 (16). pp. 798-804. ISSN 10288880 (ISSN)

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Abstract

Urtica dioica L. (Stinging nettle) has already been known for a long time as a medicinal plant in the world. This histopathological and morphometrical study was conducted to determine the effects of the hydroalcoholic extract of Urtica dioica leaves on testis of streptozotocin-induced diabetic rats. Eighteen male Wistar rats were allocated to equally normal, diabetic and treatment groups. Hyperglycemia was induced by Streptozotocin (80 mg kg -1) in animals of diabetic and treatment groups. One week after STZ injection (80 mg kg -1), the rats of treatment group received the extract of U. dioica (100 mg/kg/day) IP for 28 days. After 5 weeks of study, all the rats were sacrificed and testes were removed and fixed in bouin and after tissue processing stained with H and E technique. Tubular cell disintegration, sertoli and spermatogonia cell vacuolization and decrease in sperm concentration in seminiferous tubules were seen in diabetic and treatment groups group in comparison with control. External Seminiferous Tubular Diameter (STD) and Seminiferous Epithelial Height (SEH) significantly reduced (p<0.05) in the diabetic rats compared with controls and these parameters in the treatment group were similar to diabetics animals. This study showed that hydroalcoholic extract of Urtica dioica leaves, after induction of diabetes; has no treatment effect on seminiferous tubules alterations in streptozotocin-induced diabetic rats. © 2011 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Pak. J. Biol. Sci. [Field not mapped to EPrints] C2 - 22545354 [Field not mapped to EPrints] AD - Department of Anatomical Sciences (Embryology and Histology), Golestan University of Medical Sciences, PO. Box 49175-1141, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Diabetes, Morphometry, Rat, Seminiferous tubules, Streptozotocin, Testis, Urtica dioica, plant extract, animal, article, chemistry, drug effect, experimental diabetes mellitus, glucose blood level, glucose tolerance test, histology, male, metabolism, pathology, pathophysiology, randomization, rat, testis, Urtica dioica, Wistar rat, Animals, Blood Glucose, Diabetes Mellitus, Experimental, Glucose Tolerance Test, Male, Plant Extracts, Random Allocation, Rats, Rats, Wistar, Testis, Urtica dioica
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:52
Last Modified: 20 Jun 2015 04:57
URI: http://eprints.goums.ac.ir/id/eprint/2079

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