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The role of IL-6 for predicting neonatal sepsis: A systematic review and meta-analysis

Shahkar, L. and Keshtkar, A. and Mirfazeli, A. and Ahani, A. and Roshandel, G. (2011) The role of IL-6 for predicting neonatal sepsis: A systematic review and meta-analysis. Iranian Journal of Pediatrics, 21 (4). pp. 411-417. ISSN 10184406 (ISSN)

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Abstract

Objective: Neonatal sepsis (NS) is a common and life-threatening disorder in infants. Previous studies showed that interleukin-6 (IL-6) may be a valid non-invasive and rapid method for diagnosis of NS. We conducted this review to assess the validity of IL-6 for predicting NS. Methods: This was a systematic review with meta-analysis. Embase, Medline and Web of Science databases were searched between January 1990 and December 2009. The search terms used were "cytokine", "neonate", "sepsis" and "interleukin-6". We used standard methods recommended for meta analyses of diagnostic test evaluations. The analysis was based on a summary ROC (SROC) curve. Meta-regression analysis was used to assess the effects of some confounding factors on the results of meta-analysis. Potential presence of publication bias was tested using funnel plots and the Egger test. Findings: Meta-analysis was performed on 13 publications including 353 infants with sepsis and 691 control infants. The pooled sensitivity and specificity of IL-6 was 0.79 and 0.84, respectively. The maximum joint sensitivity and specificity (i.e., the Q value) in SROC curve was 0.82 and the area under curve (AUC) was 0.89 (95% CI: 0.84-0.94). Meta-regression analysis showed that the diagnostic accuracy of IL-6 was not affected by confounding variables. The evaluation of publication bias showed that the Egger test was not significant (P=0.07). Conclusion: IL-6 seems to be a valid marker for predicting NS. It may be considered for early diagnosis of sepsis in neonatal care units. © 2011 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Iran. J. Pediatr. [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Pediatrics, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cytokines, Interlukin-6, Meta-analysis, Neonate, Sepsis, interleukin 6, chemoluminescence, diagnostic accuracy, early diagnosis, enzyme immunoassay, enzyme linked immunosorbent assay, false negative result, false positive result, human, meta analysis, newborn sepsis, predictive value, receiver operating characteristic, review, sensitivity and specificity, systematic review, validity
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 06:50
Last Modified: 16 May 2015 15:26
URI: http://eprints.goums.ac.ir/id/eprint/2076

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