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Negative performance of root extract of Onosma dichroanthum Boiss. on the burn wound healing in an animal model

Moghaddam, P.Z. and Zolfaghari, M.R. and Ghaemi, E.A. and Mazandarani, M. and Mansourian, A.R. and Taheri, S.A. (2011) Negative performance of root extract of Onosma dichroanthum Boiss. on the burn wound healing in an animal model. Archives of Clinical Microbiology, 2 (5). ISSN 19898436 (ISSN)

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Abstract

Background: Onosma dichroanthum Boiss. belongs to the Boraginaceae family which locally known as" Hava Chobeh", and it is considered as one of the most important Mountainous medicinal plants in North of Iran, Its red roots have been used by the rural healers as either singular or combination with other plants as antiseptic and anti-inflammatory to treat the burns and wound healing. Methods and Findings: In this study, the acetonic extract of plant root was used for the evaluation of its healing efficiency on burn wound model in rat. Burn induced in Wistar rats, and subsequently they were divided into five groups were treated as follow: Group-I ointment containing of extract 2%, Group-II, traditional ointment containing of goat lipid and root extract, Groups-III ointment alone, Group-IV (positive control) the standard drug (silver sulphadiazine) and Group-V (negative control) untreated rats. The assessment the burn area healing was carried out within 14 days. Our results showed that the treated group in I and II, the intensity of wound increased up to the day 8, even the wound diameter much more expanded than negative control group (group V). The best result was demonstrated by Silver sulphadiazine treated group (group IV). Conclusion: This study shows that Onosma dichroanthum Boiss. root did not have any effect on healing of burn wounds in an animal model. Further studies are requiring for assessment of this plant in combination with other plants on burn wound healing. © Under License of Creative Commons Attribution 3.0 License.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Arch. Clin. Microbiol. [Field not mapped to EPrints] AD - Islamic Azad University of Qom-Branch, Qom, Iran [Field not mapped to EPrints] AD - Department of Microbiology, Islamic Azad University of Qom-Branch, Qom, Iran [Field not mapped to EPrints] AD - Department of Microbiology, Infection Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Botany, Islamic Azad University of Gorgan-Branch, Gorgan, Iran [Field not mapped to EPrints] AD - Biochemistry and Metabolic Disorder Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - School of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Burn wound, Iran, Onosma dichroanthum Boiss, Root, Animalia, Boraginaceae, Capra hircus, Onosma, Rattus, Rattus norvegicus
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 08:58
Last Modified: 16 May 2015 09:12
URI: http://eprints.goums.ac.ir/id/eprint/2071

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