Golestan University of Medical Sciences Repository

Effect of DSP-4 induced central noradrenergic depletion on tactile learning in rat

Rajabi, S. and Shamsizadeh, A. and Amini, H. and Shirazi, M. and Allahtavakoli, M. and Abbasnejad, M. and Sheibani, V. (2012) Effect of DSP-4 induced central noradrenergic depletion on tactile learning in rat. Neurological Research, 34 (1). pp. 80-84. ISSN 01616412 (ISSN)

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Abstract

Objective: There is general agreement that norepinephrine could modulate neuronal responses to nonmonoaminergic synaptic inputs in the somatosensory cortex. In the present study, we investigated the effect of central norepinephrine depletion on tactile learning in rats. Methods: Central norepinephrine depletion was induced using 50 mg/kg of N-(2-chloroethyl)-N-ethyl-2 bromobenzylamine (DSP-4) and verified by high performance liquid chromatography. Memory performance was assessed 1 and 5 weeks after DSP-4 treatment using novel object recognition test. Result: We observed a learning impairment in both DSP-4 groups, as the preference index was not significantly altered when compared to chance level (50%). Discussion: These findings suggest that depletion of central norepinephrine by DSP-4 leads to impairment of the tactile learning in rats, which can last at least for 35 days. © W. S. Maney & Son Ltd 2012.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Neurol. Res. [Field not mapped to EPrints] C2 - 22196866 [Field not mapped to EPrints] AD - Kerman neuroscience research centre, Kerman University of Medical Sciences, Iran [Field not mapped to EPrints] AD - Department of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman, Iran [Field not mapped to EPrints] AD - Physiology-Pharmacology Research Centre, Rafsanjan University of Medical Sciences, Iran [Field not mapped to EPrints] AD - Department of Pharmacology, Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Norepinephrine, Rat, Tactile learning, 2 bromo n (2 chloroethyl) n ethylbenzylamine, noradrenalin, animal experiment, article, controlled study, high performance liquid chromatography, learning, learning disorder, male, nonhuman, rat, tactile memory, Adrenergic Agents, Animals, Benzylamines, Brain, Learning, Male, Memory, Norepinephrine, Rats, Rats, Wistar, Recognition (Psychology)
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:51
Last Modified: 17 Oct 2016 09:38
URI: http://eprints.goums.ac.ir/id/eprint/2060

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