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99 mTc-MIBI washout as a complementary factor in the evaluation of idiopathic dilated cardiomyopathy (IDCM) using myocardial perfusion imaging

Shiroodi, M.K. and Shafiei, B. and Baharfard, N. and Gheidari, M.E. and Nazari, B. and Pirayesh, E. and Kiasat, A. and Hoseinzadeh, S. and Hashemi, A. and Akbarzadeh, M.A. and Javadi, H. and Nabipour, I. and Assadi, M. (2012) 99 mTc-MIBI washout as a complementary factor in the evaluation of idiopathic dilated cardiomyopathy (IDCM) using myocardial perfusion imaging. International Journal of Cardiovascular Imaging, 28 (1). pp. 211-217. ISSN 15695794 (ISSN)

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Abstract

Rapid technetium-99 m methoxyisobutylisonitrile (99 mTc-MIBI) washout has been shown to occur in impairedmyocardia. This study is based on the hypothesis that scintigraphy can be applied to calculate the myocardial 99 mTc-MIBI washout rate (WR) to diagnose and evaluate heart failure severity and other left ventricular functional parameters specifically in idiopathic dilated cardiomyopathy (IDCM) patients. Patients with IDCMP (n = 17; 52.65 ± 11.47 years) and normal subjects (n = 6; 49.67 ± 10.15 years)were intravenously administered 99 mTc-hexakis-2-methoxyisobutylisonitrile (99 mTc-MIBI). Next, early and delayed planar data were acquired (at 3.5-h intervals), and electrocardiogram (ECG)-gated myocardial perfusion single photon emission computed tomography (SPECT) was performed. The 99 mTc-MIBI WR was calculated using early and delayed planar images. Left ventricular functional parameters were also analyzed using quantitative gated SPECT (QGS) data. In target group, myocardial WRs (29.13 ± 6.68%) were significantly higher than those of control subjects (14.17 ± 3.31%; P < 0.001). The 99 mTc-MIBI WR increased with the increasing severity of the NYHA functional class (23.16 ± 1.72% for class I, 30.25 ± 0.95%for class II, 32.60 ± 6.73%for class III, and 37.50 ± 7.77% for class IV; P = 0.02). The WR was positively correlated with the end-diastolic volume (EDV) index (r 2 = 0.216; β = 0.464; P = 0.02 [ml/m 2], the end-systolic volume (ESV) index (r 2 = 0.234; β = 0.484; P = 0.01 [ml/m 2]), the summed motion score (SMS) (r 2 = 0.544; β = 0.738; P = 0.00), and the summed thickening score (STS) (r 2 = 0.656; β = 0.810; P = 0.00); it was negatively correlated with the left ventricular ejection fraction (LVEF) (r 2 = 0.679; β = -0.824; P = 0.00). It can be concluded that 99 mTc-MIBI scintigraphy might be a valuable molecular imaging tool for the diagnosis and evaluation of myocardial damage or dysfunction severity. © Springer Science+Business Media, B.V. 2010.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Card. Imaging [Field not mapped to EPrints] C2 - 21188639 [Field not mapped to EPrints] AD - Department of Nuclear Medicine, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Cardiology, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran [Field not mapped to EPrints] AD - Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Moallem Street, 75146-33191 Bushehr, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: 99 mTc-sestamibi scintigraphy, Gated SPECT, Idiopathic dilated cardiomyopathy, Washout rate, methoxy isobutyl isonitrile technetium tc 99m, methoxy isobutyl isonitrile technetium tc 99m, radiopharmaceutical agent, adult, article, clinical article, congestive cardiomyopathy, controlled study, disease severity, electrocardiogram, female, heart left ventricle ejection fraction, heart left ventricle enddiastolic pressure, heart left ventricle endsystolic volume, heart left ventricle function, human, image analysis, male, myocardial perfusion imaging, radioactivity, single photon emission computer tomography, washout rate, cardiac gated imaging, congestive cardiomyopathy, electrocardiography, hospitalization, methodology, middle aged, nonparametric test, scintiscanning, Cardiomyopathy, Dilated, Electrocardiography, Female, Gated Blood-Pool Imaging, Humans, Male, Middle Aged, Myocardial Perfusion Imaging, Radiopharmaceuticals, Severity of Illness Index, Statistics, Nonparametric, Technetium Tc 99m Sestamibi, Tomography, Emission-Computed, Single-Photon
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2015 09:12
Last Modified: 13 May 2015 05:35
URI: http://eprints.goums.ac.ir/id/eprint/2056

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