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Preconditioning effects of oxytocin in reducing cardiac arrhythmias in a rat heart regional ischemia-reperfusion model

Faghihi, M. and Alizadeh, A.M. and Khori, V. and Khodayari, H. and Moradi, S. (2012) Preconditioning effects of oxytocin in reducing cardiac arrhythmias in a rat heart regional ischemia-reperfusion model. Physiology and Pharmacology, 16 (4). pp. 393-403. ISSN 17350581 (ISSN)

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Abstract

Introduction: Occurrence of cardiac arrhythmias and myocardial infarction are two main deleterious events that are caused by ischemia-reperfusion (IR) injury in the heart. Cardiac preconditioning represents the most potent method of rescuing heart tissue from undergoing irreversible ischemic damage. The aim of the present study was to evaluate oxytocin (OT) cardioprotective effects and its signaling pathways in cardiac arrhythmias including ventricular tachycardia (VT) and ventricular fibrillation (VF) in anesthetized rats. Methods: Fifty-four rats were divided into nine groups. Animals' hearts were subjected to 25 min ischemia and 2 h reperfusion. Oxytocin was used 25 min prior to ischemia. In certain groups, atosiban (an oxytocin receptor antagonist), atractyloside (an opener of mitochondrial permeability transition pore, mPTP) and N-acetylcysteine (a reactive oxygen species scavenger) were used 10 min prior to OT administration. Then, the severity and incidence of cardiac arrhythmias including VT and VF were measured. Results: OT administration significantly decreased the severity and incidence of cardiac arrhythmias compared to the IR group (P<0.05). Administration of atosiban, atractyloside and N-acetylcysteine abolished the cardiac preconditioning effect of OT in cardiac arrhythmia (P<0.05). Conclusion: The present study demonstrates that preconditioning with oxytocin reduced ischemia-reperfusioninduced ventricular arrhythmias and its signaling pathways are probably mediated through mitochondrial permeability transition pore and reactive oxygen species.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - Persian [Field not mapped to EPrints] J2 - Physiol. Pharmacol. [Field not mapped to EPrints] AD - Dept. of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Cardiovascular Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Islamic Azad University, Tehran Pharmaceutical Sciences Branch, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Atractyloside, Cardiac arrhythmia, Ischemia-reperfusion, N-acetylcysteine, Oxytocin, acetylcysteine, atosiban, atractyloside, oxytocin, animal tissue, article, controlled study, disease severity, heart arrhythmia, heart muscle ischemia, heart protection, heart ventricle fibrillation, heart ventricle tachycardia, ischemic preconditioning, morbidity, nonhuman, rat, reperfusion injury
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 05:07
Last Modified: 25 Oct 2016 07:57
URI: http://eprints.goums.ac.ir/id/eprint/2052

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