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Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer

Ghaemi, A. and Soleimanjahi, H. and Razeghi, S. and Gorji, A. and Tabaraei, A. and Moradi, A. and Alizadeh, A. and Vakili, M.A. (2012) Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer. Iranian Journal of Immunology, 9 (2). pp. 119-127. ISSN 17351383 (ISSN)

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Abstract

Background: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. Objective: The potential immunomodulatory effects of genistein on the immune system and against TC-1 tumor cell line were evaluated in adult female C57BL/6 mice. Methods: Mice were treated with GEN 10 days before to 10 days after the tumor induction. Thirty days after the last GEN treatment, lymphocyte proliferation, Lactase Dehydrogenase (LDH) cytolytic activity and cytokine secretion were analyzed in GEN and control groups. Results: The results showed that ingestion of genistein significantly increased lymphocyte proliferation and LDH release. Furthermore, the treatment with genistein also caused a significant increment in interferon gamma (IFN-γ). In addition, the treatment achieved significant therapeutic effect in tumor models compared to the control group. These results indicated that the effect of GEN on tumor growth may be attributed to its effect on lymphocyte proliferation, cytolytic activity and IFN-γ production. Conclusion: These results demonstrate that GEN exerts an immunomodulatory effect in a mouse model of Human Papillomavirus (HPV) associated-cervical cancer.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Iran. J. Immunol. [Field not mapped to EPrints] C2 - 22735799 [Field not mapped to EPrints] AD - Department of Microbiology, School of Medicine, Infectious Diseases research Centre, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Shefa Neuroscience Research Centre, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Institut für Physiologie I, Westfälische Wilhelms-Universität Münster, Robert-Koch-Strasse Münster, Germany [Field not mapped to EPrints] AD - Department of Advanced Technology, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Health and Social Sciences, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cervical cancer, Genistein, Human papillomavirus, Imunomodulation, TC-1, gamma interferon, genistein, lactate dehydrogenase, animal cell, animal experiment, article, cancer inhibition, controlled study, cytokine release, cytolysis, drug effect, enzyme activity, enzyme release, female, immunomodulation, lymphocyte proliferation, mouse, nonhuman, uterine cervix cancer, Alphapapillomavirus, Animals, Anticarcinogenic Agents, Cell Line, Tumor, Cell Proliferation, Cytotoxicity, Immunologic, Female, Genistein, Humans, Immunomodulation, Interferon-gamma, L-Lactate Dehydrogenase, Mice, Mice, Inbred C57BL, Neoplasms, Experimental, Papillomavirus Infections, Soybeans, T-Lymphocytes, Uterine Cervical Neoplasms
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 06:32
Last Modified: 11 May 2015 15:15
URI: http://eprints.goums.ac.ir/id/eprint/2051

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