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Acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation

Khori, V. and Shariatnezhad, S. and Alizadeh, A.M. and Yazdi, H. and Pourabouk, M. and Badaghabadi, F. and Rajaei, M. and Moheimani, H. and Saleki, S. and Nayebpour, M. (2012) Acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation. Physiology and Pharmacology, 15 (4). pp. 507-516. ISSN 17350581 (ISSN)

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Abstract

Introduction: Previous studies have indicated a relationship between MPTP pore and AV nodal rate-dependent properties. The aim of present study was to determine acute direct effects of cyclosporine on extracellular field potential of isolated rabbit AV node during experimental atrial fibrillation. Methods: In one group of male New Zealand rabbits (1.5-2.5 kg) cumulative concentrations of cyclosporine (0.5 -10 μm) were applied on isolated perfused atrio-nodal preparation (n=7). Extracellular field potential recording was sampled during specific stimulation protocols (recovery, zone of concealment and atrial fibrillation) in the presence of drug on electrophysiological properties of AV-node. Results: Cyclosporine significantly decreased the ventricular rate (HH mean) from 231.8 ± 5.7 to 277.4 ± 14.6 msec and functional refractory period during AF (AF FRP) from 138.3 ± 7.5 to 161.2 ± 10.31 msec in control and treated groups, respectively. Effective refractory period during AF (AF ERP) was significantly decreased by cyclosporine 10 mM compared to control group (p<0.05). Conclusion: Cyclosporine-evoked slowing ventricular heart rate during AF was induced by increasing functional refractoy period and ZOC. A possible mechanism can be through blocking of MPT pores.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - Persian [Field not mapped to EPrints] J2 - Physiol. Pharmacol. [Field not mapped to EPrints] AD - Golestan Cardiovascular Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Dept. Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Atrial fibrillation, Atrio-ventricular node, Cyclosporine, Mitochondrial permeability transitional pores, cyclosporin, animal experiment, animal model, Article, controlled study, drug effect, experimental atrial fibrillation, extracellular field potential, heart atrioventricular node, heart electrophysiology, heart muscle refractory period, heart rate, heart ventricle, nonhuman, rabbit
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2015 09:25
Last Modified: 25 Oct 2016 07:55
URI: http://eprints.goums.ac.ir/id/eprint/2050

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