Golestan University of Medical Sciences Repository

Serum hyaluronic acid and laminin as potential tumor markers for upper gastrointestinal cancers

Aghcheli, K. and Parsian, H. and Qujeq, D. and Talebi, M. and Mosapour, A. and Khalilipour, E. and Islami, F. and Semnani, S. and Malekzadeh, R. (2012) Serum hyaluronic acid and laminin as potential tumor markers for upper gastrointestinal cancers. European Journal of Internal Medicine, 23 (1). pp. 58-64. ISSN 09536205 (ISSN)

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Abstract

Background: Early diagnosis of patients with upper gastrointestinal cancer is important because many cases are diagnosed in advanced stages and have poor prognosis. Several studies have reported increased serum levels of hyaluronic acid and laminin in various cancers and the correlation of the levels with poor prognosis. However, little data on the use of serum hyaluronic acid and laminin levels for early detection of esophageal and gastric cancers are available. Methods: We assessed serum hyaluronic acid and laminin levels using enzyme-linked immunosorbent assay in 20 gastric cardia cancer, 23 gastric noncardia cancer and 20 esophageal squamous cell carcinoma incident cases and 25 controls in the Golestan Province, northern Iran, a high risk area for upper gastrointestinal cancers. Results: Mean serum hyaluronic acid and laminin concentrations in cancer cases were higher than in controls in crude analyses. Significant correlations were observed between hyaluronic acid levels and gastric noncardia cancer (Beta-coefficient = 0.390; P = 0.01) and esophageal squamous cell carcinoma (Beta-coefficient = 0.332; P = 0.05) and between laminin levels and gastric cardia cancer (Beta-coefficient = 0.454; P = 0.003) in multivariate models. For esophageal squamous cell carcinoma, gastric cardia cancer, and gastric noncardia cancer, area under ROC curve (AUC) of hyaluronic acid was 0.708, 0.694, and 0.770, and of laminin was 0.706, 0.828, and 0.671. Conclusions: Our study suggests that hyaluronic acid and laminin may be used to identify potentially high-risk groups of upper gastrointestinal cancers for further diagnostic work-ups, particularly in high incidence areas. Nevertheless, further studies with larger sample size and tumor staging information are warranted to clarify the clinical significance of hyaluronic acid and laminin in those cancers. © 2011 European Federation of Internal Medicine.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Eur. J. Intern. Med. [Field not mapped to EPrints] C2 - 22153533 [Field not mapped to EPrints] AD - Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Ganjafrooz Avenue, Babol, Iran [Field not mapped to EPrints] AD - Cellular and Molecular Biology Research Centre, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Department of Laboratory Sciences, Mazandaran University of Medical Sciences, Sari, Iran [Field not mapped to EPrints] AD - International Agency for Research on Cancer, Lyon, France [Field not mapped to EPrints] AD - King's College London, Thames Cancer Registry, London, United Kingdom [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cardia cancer, Esophageal cancer, Esophageal squamous cell carcinoma, Hyaluronic acid, Laminin, hyaluronic acid, laminin, adult, aged, article, cancer diagnosis, cancer risk, controlled study, diagnostic accuracy, diagnostic test accuracy study, enzyme linked immunosorbent assay, esophageal squamous cell carcinoma, female, human, major clinical study, male, outcome assessment, predictive value, receiver operating characteristic, sensitivity and specificity, stomach adenocarcinoma, Adenocarcinoma, Aged, Carcinoma, Squamous Cell, Case-Control Studies, Esophageal Neoplasms, Female, Humans, Hyaluronic Acid, Laminin, Male, Middle Aged, Stomach Neoplasms, Tumor Markers, Biological
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:04
Last Modified: 11 May 2015 06:31
URI: http://eprints.goums.ac.ir/id/eprint/2048

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