Khori, V. and Naeimipour, S. and Alizadeh, A.M. and Rouhani, A.H. and Pourabouk, M. and Badaghabadi, F. and Rajaei, M. and Shariatnezhad, S. and Moheimani, H. and saleki, S. and Zeyghami, M.A. and Nayebpour, M. (2012) Frequency-dependent electrophysiological properties of concealed slow pathway of isolated rabbit atrioventricular node preparation after fast pathway ablation in a functional model. Physiology and Pharmacology, 16 (1). pp. 21-32. ISSN 17350581 (ISSN)
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Abstract
Introduction: Intranodal pathways of atrioventricular (AV) node play a vital role in the delay of conduction time in response to various atrial inputs. The present study was aimed to determine the frequency-dependent electrophysiological properties of concealed slow pathway according to a functional model of isolated rabbit atrioventricular node preparation after fast pathway ablation. Methods: Experiments were carried out in rabbit isolated heart AV-nodal preparations (N=8) by superfused/perfused mode. Extracellular recording was carried out from transitional cells of posterior and anterior extension of AV-node and upper part of atrium and its bundle. Unipolar silver electrode (100 μm) and direct voltage (100-110 V) was applied to create AV-nodal fast pathway ablation. Results: Minimum conduction time (AHmin) was significantly increased after fast pathway ablation (p<0.05). Fast pathway ablation had no significant impact on fatigue phenomenon but significantly reduced facilitation value (p<0.05). Rate-dependency properties of concealed slow pathway were explained according to functional nodal model. Conclusion: The mathematical functional model accurately simulated frequency-dependent electrophysiological properties of concealed slow pathway after fast pathway ablation, but some modifications are necessary for accurate prediction of nodal behavior in various cycle lengths and in arrhythmia. Concealed slow pathway may be considered as a potential electrophysiological substrate of fatigue and facilitation phenomenon.
| Item Type: | Article |
|---|---|
| Additional Information: | Unmapped bibliographic data: LA - Persian [Field not mapped to EPrints] J2 - Physiol. Pharmacol. [Field not mapped to EPrints] AD - Golestan Cardiovascular Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Dept. Biology, Science and research branch, Islamic azad university, Tehran, Iran [Field not mapped to EPrints] AD - Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Dept. Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] |
| Uncontrolled Keywords: | Ablation atrioventricular node, Concealed slow pathway, Fast pathway, Mathematical analysis, ablation therapy, animal experiment, animal model, Article, fast pathway ablation, heart arrhythmia, heart atrioventricular node, heart electrophysiology, mathematical model, nonhuman, quantitative analysis, rabbit |
| Subjects: | مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus موارد کلی |
| Divisions: | معاونت تحقیقات و فناوری |
| Depositing User: | GOUMS |
| Date Deposited: | 20 Apr 2015 08:43 |
| Last Modified: | 25 Oct 2016 07:56 |
| URI: | http://eprints.goums.ac.ir/id/eprint/2047 |
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