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The effect of 12 weeks Anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; A randomized double blind controlled trial

Mansouri, M. and Nayebi, N. and Keshtkar, A. and Hasani-Ranjbar, S. and Taheri, E. and Larijani, B. (2012) The effect of 12 weeks Anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; A randomized double blind controlled trial. DARU, Journal of Pharmaceutical Sciences, 20 (1). ISSN 15608115 (ISSN)

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Abstract

Background: The clustering of metabolic abnormalities defined as metabolic syndrome is now both a public health and a clinical problem .While interest in herbal medicine has greatly increased, lack of human evidence to support efficacies shown in animals does exist. This clinical trial study designed to investigate whether herbal medicine, Anethum graveolens (dill) extract, could improve metabolic components in patients with metabolic syndrome. Methods: A double-blind, randomized, placebo-controlled trial using a parallel design was conducted. 24 subjects who had metabolic syndrome diagnostic criteria (update of ATP III) were randomly assigned to either dill extract (n = 12) or placebo (n = 12) for 3 months. Results: Across lipid component of metabolic syndrome, no significant differences in triglyceride (TG) concentration and high density lipoprotein cholesterol were seen between the two groups. However TG improved significantly from baseline (257.0 vs. 201.5p = 0.01) with dill treatment but such a significant effect was not observed in placebo group. Moreover, no significant differences in waist circumference, blood pressure and fasting blood sugar were seen between two groups after 3 months follow up period. Conclusion: In this small clinical trial in patients with metabolic syndrome, 12 weeks of dill extract treatment had a beneficial effect in terms of reducing TG from baseline. However dill treatment was not associated with a significant improvement in metabolic syndrome related markers compared to control group. Larger studies might be required to prove the efficacy and safety of long-Term administration of dill to resolve metabolic syndrome components. © 2012 Mansouri et al.; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - 47 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - DARU J. Pharm. Sci. [Field not mapped to EPrints] AD - Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Gastroenterology and Hepatology Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Abdominal obesity, Anethum graveolens, Clinical trial, Dill, Hyperlipidemia, Metabolic syndrome, alanine aminotransferase, albumin, alkaline phosphatase, anethum graveolens extract, aspartate aminotransferase, bilirubin, biological marker, creatinine, electrolyte, glucose, high density lipoprotein cholesterol, placebo, plant extract, triacylglycerol, unclassified drug, adult, alanine aminotransferase blood level, alkaline phosphatase blood level, article, aspartate aminotransferase blood level, bilirubin blood level, blood pressure, cholesterol blood level, clinical article, controlled study, creatinine blood level, dill, double blind procedure, drug efficacy, drug safety, drug tolerability, electrolyte blood level, electrolyte disturbance, female, follow up, glucose blood level, hematologic disease, human, leukocyte count, male, metabolic disorder, metabolic parameters, metabolic syndrome X, parallel design, randomized controlled trial, triacylglycerol blood level, waist circumference
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:35
Last Modified: 12 May 2015 06:25
URI: http://eprints.goums.ac.ir/id/eprint/2046

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