Golestan University of Medical Sciences Repository

The effect of intravenous vitamin C on the phosphorus level reduction in hemodialysis patients: A double blind randomized clinical trial

Baradari, A.G. and Zeydi, A.E. and Espahbodi, F. and Aarabi, M. (2012) The effect of intravenous vitamin C on the phosphorus level reduction in hemodialysis patients: A double blind randomized clinical trial. Medicinski Glasnik, 9 (1). pp. 37-41. ISSN 18400132 (ISSN)

[img]
Preview
PDF - Published Version
Download (440kB) | Preview

Abstract

Aim The majority of hemodialysis patients are hyperphosphate-mic. Hyperphosphatemia in these patients can lead to renal oste-odystrophy, vascular calcifcation, cardiovascular events, and is independently associated with mortality risk. The aim of this study was to evaluate the effect of intravenous vitamin C on phosphorus level in hemodialysis patients. Methods Using a double blind randomized clinical trial, a total of 60 qualified hemodialysis patients were randomly allocated in two intervention and control groups and serum phosphorus, CRP, calcium, albumin and PTH levels were measured. At the end of each hemodialysis session, intervention group received vitamin C vial (500mg/5cc) intravenously three times a week for 8 weeks and control group received normal saline in the same way. Data were collected before and after two months of treatment. Data were analyzed using independent t-test, paired t-test and chi-square test. Results Vitamin C treated group had a significant decrease in phosphorus (p=0.01), CRP level (p=0.01) and Ca�P product (p=0.03). In contrast, there was no significant difference in phosphorous (p= 0.5) and CRP levels (p= 0.6) and Ca�P product (p=0.7) in the control group. In addition, there was no statistically significant change in calcium (p=0.1), PTH (p=0.4) and albumin (p=0.4) levels in both groups. Conclusion Intravenous vitamin C can significantly decrease phosphorus level in hemodialysis patients.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English; Croatian [Field not mapped to EPrints] J2 - Med. Glas. [Field not mapped to EPrints] C2 - 22634906 [Field not mapped to EPrints] AD - Department of Medical Surgical Nursing, Nasibeh Nursing and Midwifery Faculty, Vesal Street, Amir Mazandarani Boulevard, Sari, Iran [Field not mapped to EPrints] AD - Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Iran [Field not mapped to EPrints] AD - Department of Nephrology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran [Field not mapped to EPrints] AD - Department of Epidemiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Ca�P product, CRP, Hemodialysis, Hyperphospha-temia, Phosphorus, Vitamin C, ascorbic acid, C reactive protein, calcium, parathyroid hormone, phosphorus, placebo, adult, aged, article, controlled study, double blind procedure, drug effect, female, hemodialysis, hemodialysis patient, human, major clinical study, male, phosphate blood level, randomized controlled trial, treatment duration, Adult, Aged, Ascorbic Acid, C-Reactive Protein, Calcium, Double-Blind Method, Female, Humans, Hyperphosphatemia, Infusions, Intravenous, Male, Middle Aged, Phosphorus, Renal Dialysis, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 05:11
Last Modified: 11 May 2015 07:40
URI: http://eprints.goums.ac.ir/id/eprint/2042

Actions (login required)

View Item View Item