Golestan University of Medical Sciences Repository

Tissue Inhibitors of Matrix Metalloproteinase-3, Potential Therapeutic Target against Multiple Sclerosis

Ghaemi, A. and Hamdi, K. and Togha, M. and Kazemi, H. and Gorji, A. (2012) Tissue Inhibitors of Matrix Metalloproteinase-3, Potential Therapeutic Target against Multiple Sclerosis. American Journal of Biochemistry and Molecular Biology, 2 (3). pp. 195-199. ISSN 21504210 (ISSN)

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Abstract

The Matrix Metalloproteinase Proteins (MMPs) comprise a large group of endoproteinases that cleave most, if not all, components of the extracellular matrix. The activities of MMPs are modulated by manipulation in the levels of natural MMP inhibitors, the "Tissue Inhibitors of Metallo Proteinases" (TIMPs). In a pathological processes of Multiple Sclerosis (MS), the MMP-2 and 9 (Gelatinase) are over expressed and balance of TIMP and MMP expression is perturbed, leading to locally increased proteolytic activity of Gelatinase and uncontrolled degradation of the Blood Brain Barrier (BBB) and myelin basic protein. Therefore, Gelatinase are the main mediators in the evolution of MS and TIMP has been proposed as a novel therapeutic target for MS therapy. © 2012 Academic Journals Inc.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Am. J. Biochem. Mol. Biol. [Field not mapped to EPrints] AD - Department of Microbiology, School of Medicine, Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Microbiology, Tehran Sciences and Research Branch of IAU, Tehran, Iran [Field not mapped to EPrints] AD - Young Researchers Club, Science and Research Branch, Islamic Azad University, Tehran, Iran [Field not mapped to EPrints] AD - Department of Neurology, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Shefa Neuroscience Research Center, Tehran, Iran [Field not mapped to EPrints] AD - Department of Pediatric, Shahed University, Tehran, Iran [Field not mapped to EPrints] AD - Institut fur Physiologe I, Westfalische Wilhelms-Universitat Munster, Robert-Kmh-Strasse Munster, Germany [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Matrix metallo proteinase proteins, Multiple sclerosis, Therapeutic target, Tissue inhibitors of metalloproteinases, gelatinase A, gelatinase B, matrilysin, myelin basic protein, neutrophil collagenase, tissue inhibitor of metalloproteinase 3, allergic encephalomyelitis, article, astrocyte, blood brain barrier, disease model, enzyme activity, enzyme specificity, extracellular matrix, human, macrophage, microglia, multiple sclerosis, nonhuman, pathogenesis, protein degradation, protein expression, T lymphocyte
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 08:50
Last Modified: 20 Jun 2015 04:55
URI: http://eprints.goums.ac.ir/id/eprint/2039

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