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Effect of scopolamine-based amnesia on the number of astrocytes in the rat's hippocampus

Jahanshahi, M. and Azami, N.S. and Nickmahzar, E. (2012) Effect of scopolamine-based amnesia on the number of astrocytes in the rat's hippocampus. International Journal of Morphology, 30 (2). pp. 388-393. ISSN 07179367 (ISSN)

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Abstract

As neuron-astrocyte interactions play a crucial role in the adult brain, it is thought that astrocytes support learning and memory through specific mechanisms. In this study, the effect of scopolamine based amnesia on the number of astrocytes in rats' hippocampus was studied. Adult male albino Wistar rats were bilaterally cannulated into the CA1 region and animals received saline or different doses of scopolamine (0.5, 1 and 2 mg/ rat, intra - CA1), immediately after training. Then all the rats were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH. The area densities of the astrocytes in dentate gyrus were measured and compared in the all groups (p < 0.05). Data showed that post-training scopolamine (0.5, 1 and 2 μg/rat, intra-CA1) dose-dependently reduced the step-through latency in the inhibitory avoidance task, showing scopolamineinduced amnesia. Also we found different response of astrocytes in different subfields of hippocampal formation. In dentate gyrus the number of astrocytes was increased, but in other areas scopolamine can decreased the density of astrocytes. We concluded that scopolamine can cause amnesia and this phenomenon can have an effect on astrocyte numbers in the rats hippocampal formation.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English; Spanish [Field not mapped to EPrints] ST - Efecto de la amnesia inducida por escopolamina sobre el número de astrocitos en el hipocampo de ratas [Field not mapped to EPrints] J2 - Int. J. Morphol. [Field not mapped to EPrints] AD - Neuroscience Research Center, Department of Anatomy, Faculty of Medicine, Golestaan University of medical Sciences, Gorgan-Sari road (Shastcola), P.O. Box: 49175-553, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran [Field not mapped to EPrints] AD - Neuroscience Research Center, Golestan University of medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Amnesia, Astrocyte, Hippocampus, Rat, Scopolamine
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 03:37
Last Modified: 11 May 2015 16:56
URI: http://eprints.goums.ac.ir/id/eprint/2005

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