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Frequency-dependent electrophysiological remodeling of the AV node by hydroalcohol extract of Crocus sativus L. (saffron) during experimental atrial fibrillation: The role of endogenous nitric oxide

Khori, V. and Alizadeh, A.M. and Yazdi, H. and Rakhshan, E. and Mirabbasi, A. and Changizi, S. and Mazandarani, M. and Nayebpour, M. (2012) Frequency-dependent electrophysiological remodeling of the AV node by hydroalcohol extract of Crocus sativus L. (saffron) during experimental atrial fibrillation: The role of endogenous nitric oxide. Phytotherapy Research, 26 (6). pp. 826-832. ISSN 0951418X (ISSN)

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Abstract

The study assessed the hydroalcohol extract effects of Crocus sativus L. (saffron) on (i) the basic and rate-dependent electrophysiological properties of the AV node, (ii) remodeling of the AV node during experimental atrial fibrillation (AF) and (iii) the role of nitric oxide (NO) in the effects of saffron on the AV node. Stimulation protocols in isolated AV node were used to quantify AV nodal recovery, facilitation and fatigue in four groups of rabbits (n = 8-16 per group). In addition, the nodal response to AF was evaluated at multiple cycle lengths and during AF. Saffron had a depressant effect on AV nodal rate-dependent properties; further, it increased Wenckebach block cycle length, functional refractory period, facilitation and fatigue (p < 0.05). A NO-synthase inhibitor (L-NAME) prevented the depressant effects of saffron on the AV node (p < 0.05). Saffron increased the zone of concealment in experimental AF (p < 0.05). The present research showed, for the first time, established electrophysiological remodeling of the AV node during AF by saffron. Saffron increased the AV nodal refractoriness and zone of concealment. These depressant effects of saffron were mediated by endogenous NO. Copyright © 2011 John Wiley & Sons, Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Phytother. Res. [Field not mapped to EPrints] C2 - 22072550 [Field not mapped to EPrints] AD - Golestan Cardiovascular Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Cancer Research Center, Tehran University of Medical Science, Tehran, Iran [Field not mapped to EPrints] AD - Department of Botany, Islamic Azad University, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: arrhythmia, atrial fibrillation, atrioventricular node, saffron, alcohol, Crocus sativus extract, n(g) nitroarginine methyl ester, nitric oxide, verapamil, animal tissue, article, atrioventricular conduction, concentration response, controlled study, drug effect, facilitation, fatigue, heart atrioventricular node, heart atrium fibrillation, heart electrophysiology, heart muscle refractory period, heart stimulation, in vitro study, isolated heart, male, nonhuman, rabbit, Wenckebach period, Animals, Anti-Arrhythmia Agents, Atrial Fibrillation, Atrioventricular Node, Crocus, Electrophysiological Phenomena, Ethanol, Fatigue, Heart Block, Heart Rate, Male, NG-Nitroarginine Methyl Ester, Nitric Oxide, Plant Extracts, Rabbits, Water, Crocus sativus, Oryctolagus cuniculus
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 08:43
Last Modified: 25 Oct 2016 07:56
URI: http://eprints.goums.ac.ir/id/eprint/2003

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