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Protective role of simvastatin on isolated rabbit atrioventricular node during experimental atrial fibrillation model: Role in rate control of ventricular beats

Khori, V. and Najafi, S.A. and Alizadeh, A.M. and Moheimani, H.R. and Shakiba, D. and Alizadeh, F. and Nayebpour, M. (2012) Protective role of simvastatin on isolated rabbit atrioventricular node during experimental atrial fibrillation model: Role in rate control of ventricular beats. Naunyn-Schmiedeberg's Archives of Pharmacology, 385 (7). pp. 697-706. ISSN 00281298 (ISSN)

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Abstract

The purpose of the present study was to determine (1) whether simvastatin (SV) modifies the ratedependent conduction time and refractoriness of the atrioventricular (AV) node and (2) how it can change the protective mechanism of the AV node during atrial fibrillation (AF). Predefined stimulation protocols were applied to detect the electrophysiological parameters of the AV node, including atrial-His conduction time, effective refractory period (ERP), functional refractory period (FRP), concealed conduction, excitable index, and fatigue in two groups of isolated, perfused rabbit AV nodal preparations (N016). The stimulation protocols (fatigue, recovery) were carried out during control and in the presence of SV (0.5, 0.8, 3, and 10 μM). Simulated AF was executed in a separate group (N08), and specific indexes, including H-H mean, zone of concealment (ZOC), and concealed beats were recorded. SV, in a concentration-dependent manner, prolonged ERP, FRP, and Wenckebach cycle lengths. It (10 μM) significantly increased fatigue and the excitable index. In addition, SV elicited prolongation of ZOC and H-H mean at 3 and 10 μM. SV-evoked prolongation of nodal refractoriness and concealed conduction caused ratedependent ventricular slowing effects during AF. The ability of simvastatin to decrease the excitable gap by its heterogeneous effects on nodal dual pathways proposes its protective role in AF. © Springer-Verlag 2012.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Naunyn-Schmiedeberg's Arch. Pharmacol. [Field not mapped to EPrints] C2 - 22538640 [Field not mapped to EPrints] AD - Golestan Cardiovascular Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Cancer Research Center of Cancer Institute, Tehran University of Medical Science, Tehran, Iran [Field not mapped to EPrints] AD - Department of Pharmacology and Toxicology, Tehran University of Medical Sciences, P.O Box 14395-477, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Atrial fibrillation, Atrioventricular node, Concealment zone, Excitable index, Simvastatin, simvastatin, animal tissue, article, atrioventricular conduction, cardiovascular parameters, concealed beat, controlled study, dose response, drug effect, drug mechanism, excitable index, experimental model, heart atrioventricular node, heart atrium fibrillation, heart conduction, heart electrophysiology, heart fatigue, heart muscle refractory period, heart protection, heart rate, heart stimulation, His bundle, male, nonhuman, rabbit, regulatory mechanism, Wenckebach cycle length, zone of concealment, Animals, Atrial Fibrillation, Atrioventricular Node, Cardiotonic Agents, Disease Models, Animal, Heart Rate, Male, Rabbits, Simvastatin
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:43
Last Modified: 25 Oct 2016 07:58
URI: http://eprints.goums.ac.ir/id/eprint/1994

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