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Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population

Alami, F.M. and Ahmadi, M. and Bazrafshan, H. and Tabarraei, A. and Khosravi, A. and Tabatabaiefar, M.A. and Samaei, N.M. (2012) Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population. Genetics and Molecular Biology, 35 (2). pp. 413-417. ISSN 14154757 (ISSN)

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Abstract

In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108-1.918, p = 0.007). A significant difference in TT genotype was observed between T2DM patients and normoglycemic controls (OR 2.038, 95% CI 1.147-3.623; p = 0.014). On assuming dominant and recessive models, ORs of 1.52 [95% CI (1.05-2.21) p = 0.026)] and 1.74 [95% CI (1.01-3.00) p = 0.043] were obtained, respectively, thereby implying that the co-dominant model would best fit the susceptible gene effect. This study further confirms the TCF7L2 gene as enhancing susceptibility to the development of T2DM. © 2012, Sociedade Brasileira de Genética.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Genet. Mol. Biol. [Field not mapped to EPrints] AD - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran [Field not mapped to EPrints] AD - Mazandaran University of Medical Sciences, Sari, Iran [Field not mapped to EPrints] AD - Department of Endocrinology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran [Field not mapped to EPrints] AD - Biochemistry and Metabolic Disorders Research Center, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: rs12255372 variant, Single nucleotide polymorphism (SNP), TCF7L2 gene, Type 2 diabetes mellitus (T2DM), transcription factor 7 like 2, adult, article, controlled study, female, gene, gene frequency, genetic association, genetic risk, genetic susceptibility, genetic variability, genotype, human, Iran, major clinical study, male, non insulin dependent diabetes mellitus, polymerase chain reaction, restriction fragment length polymorphism, risk assessment, single nucleotide polymorphism, transcription factor 7 like 2 gene
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:28
Last Modified: 11 May 2015 06:40
URI: http://eprints.goums.ac.ir/id/eprint/1988

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