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Concurrent silent strokes impair motor function by limiting behavioral compensation

Faraji, J. and Kurio, K. and Metz, G.A. (2012) Concurrent silent strokes impair motor function by limiting behavioral compensation. Experimental Neurology, 236 (2). pp. 241-248. ISSN 00144886 (ISSN)

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Abstract

Silent strokes occur more frequently than classic strokes; however, symptoms may go unreported in spite of lasting tissue damage. A silent stroke may indicate elevated susceptibility to recurrent stroke, which may eventually result in apparent and lasting impairments. Here we investigated if multiple silent strokes to the motor system challenge the compensatory capacity of the brain to cumulatively result in permanent functional deficits. Adult male rats with focal ischemia received single focal ischemic mini-lesions in the sensorimotor cortex (SMC) or the dorsolateral striatum (DLS), or multiple lesions affecting both SMC and DLS. The time course and outcome of motor compensation and recovery were determined by quantitative and qualitative assessment of skilled reaching and skilled walking. Rats with SMC or DLS lesion alone did not show behavioral deficits in either task. However, the combination of focal ischemic lesions in SMC and DLS perturbed skilled reaching accuracy and disrupted forelimb placement in the ladder rung walking task. These observations suggest that multiple focal infarcts, each resembling a silent stroke, gradually compromise the plastic capacity of the motor system to cause permanent motor deficits. Moreover, these findings support the notion that cortical and subcortical motor systems cooperate when adopting beneficial compensatory movement strategies. © 2012 Elsevier Inc..

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Exp. Neurol. [Field not mapped to EPrints] C2 - 22609330 [Field not mapped to EPrints] AD - Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Faculty of Nursing and Midwifery, P.O. Box 49165-568, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Brain plasticity, Dorsolateral striatum, Endothelin-1, Focal ischemia, Ladder rung walking task, Mini-stroke, Sensorimotor cortex, Skilled forelimb reaching task, animal experiment, animal model, animal tissue, article, brain infarction, brain ischemia, cerebrovascular accident, controlled study, corpus striatum, forelimb, limb movement, male, motor dysfunction, motor performance, nonhuman, priority journal, qualitative analysis, quantitative analysis, rat, sensorimotor cortex, walking, Adaptation, Physiological, Adaptation, Psychological, Animals, Behavior, Animal, Male, Motor Skills Disorders, Random Allocation, Rats, Rats, Long-Evans, Stroke
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:12
Last Modified: 11 May 2015 14:58
URI: http://eprints.goums.ac.ir/id/eprint/1984

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