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Vitamin D in ulcerative colitis: A cause or an effect?

Amiriani, T. and Barzanoni, S. and Sedighy, S. and Besharat, S. and Kelarijani, F.N. and Joshaghani, H. and Roshandel, G. and Akbari, H. (2012) Vitamin D in ulcerative colitis: A cause or an effect? Journal of Clinical and Diagnostic Research, 6 (6). pp. 1011-1013. ISSN 2249782X (ISSN)

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Abstract

Background and Aims: Vitamin D deficiency is common among patients with inflammatory bowel disease, even when the disease is in remission. This study was designed to evaluate the serum levels of 25-hydroxy vitamin D [25(OH)-D3] in patients who suffered from ulcerative colitis and the control group in Golestan province in the northeast of Iran. Methods: In this case-control study, 60 patients with a definite histopathological diagnosis of ulcerative colitis were included. The control group was selected from healthy blood donors. The serum levels of 25(OH)-D3 were measured by the ELISA method (ids- UK). Data were entered into the SPSS-16 software and were analyzed by t-test and Chi-square test. Results: The mean serum level of vitamin D in the patients was significantly lower as compared to that in the control group (P-value <0.01). The differences in the levels of 25-OH-D3 were statistically significant between the two sexes, in both groups. A normal vitamin D level was seen in all cases with proctitis, in 20% of cases in the rectosigmoiditis group and in no cases in the pan-colitis group. The difference was statistically significant (p-value <0.01). Conclusions: It can be concluded that the serum levels of vitamin D in the patients with ulcerative colitis are low and that inflammatory bowel disease can be a target for the specific vitamin D therapy.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Clin. Diagn. Res. [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Golestan Research Center of Gastroenterology and Hepatology, Iran [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Inflammatory bowel disease, Ulcerative colitis, Vitamin D, calcifediol, article, case control study, causal attribution, colon disease, computer program, controlled study, disease association, enzyme linked immunosorbent assay, female, histopathology, human, Iran, major clinical study, male, pancolitis, pathogenesis, proctitis, rectosigmoiditis, ulcerative colitis, vitamin blood level
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 08:35
Last Modified: 11 May 2015 07:25
URI: http://eprints.goums.ac.ir/id/eprint/1979

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