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Effects of omeprazole consumption on serum levels of trace elements

Joshaghani, H. and Amiriani, T. and Vaghari, G. and Besharat, S. and Molana, A. and Badeleh, M. and Roshandel, G. (2012) Effects of omeprazole consumption on serum levels of trace elements. Journal of Trace Elements in Medicine and Biology, 26 (4). pp. 234-237. ISSN 0946672X (ISSN)

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Abstract

Project: Omeprazole is one of the most frequently prescribed drugs in patients with gastroesophageal reflux disease (GERD). It increases the gastric pH and this in turn may change the intestinal absorption of trace elements. This study was conducted to assess the effects of omeprazole consumption on the serum level of trace elements. Procedures: The studied subjects were selected from the list of patients referred to the gastroenterology department of 5 Azar hospital in Golestan province of Iran for whom omeprazole was prescribed by a gastroenterologist. Blood samples were obtained before (phase I) and after an eight-week period (phase II) of omeprazole consumption. Serum levels of trace elements were assessed by the photometric method. Results: Sixty seven patients were recruited of whom, 35.82% were males. There was no significant difference in serum levels of Fe, P, Ca and Cu between phases I and II. Serum concentration of Zn was significantly lower in phase II than I (P= 0.02). The proportion of male patients with low Zn levels was significantly higher in phase II (50%) than I (16.7%) (P= 0.01). We found no significant difference in the proportion of female patients with low Zn levels between phase I (37.2%) and phase II (27.9%). Conclusions: We found no significant reduction in serum levels of Fe, P, Ca and Cu in phase II. However, our results showed that serum level of Zn was significantly lower after omeprazole consumption in males. So, nutritional supplement of Zn should be considered in male patients treated with omeprazole. © 2012 Elsevier GmbH.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Trace Elem. Med. Biol. [Field not mapped to EPrints] C2 - 22677542 [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Biochemistry and Metabolic Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Gastroesophageal reflux disease, Omeprazole, Trace elements, calcium, copper, iron, omeprazole, phosphorus, zinc, adult, article, blood sampling, calcium blood level, copper blood level, drug effect, drug use, female, gastroesophageal reflux, human, Iran, iron blood level, major clinical study, male, mean corpuscular volume, patient referral, phosphate blood level, prescription, priority journal, zinc blood level, Adult, Female, Gastroesophageal Reflux, Humans, Male, Middle Aged, Omeprazole, Trace Elements, Young Adult, Zinc
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:14
Last Modified: 12 May 2015 05:14
URI: http://eprints.goums.ac.ir/id/eprint/1966

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