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Astrocytes in molecular layer of cerebellum after spatial learning

Jahanshahi, M. and Sadeghi, Y. and Hosseini, A. and Naghdi, N. and Golalipour, M.J. (2012) Astrocytes in molecular layer of cerebellum after spatial learning. Basic and Clinical Neuroscience, 3 (2). pp. 16-21. ISSN 2008126X (ISSN)

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Abstract

Introduction: Previous studies have suggested that the cerebellum is a primary site of motor learning. The cerebellar cortex has a particular glial architecture with large astroglial cells. In addition, more recent works have revealed that astrocytes play a more active role in neuronal activity. The aim of this study was to evaluate the number of astrocytes in the molecular layer of rat's cerebellum after spatial learning. Methods: 21 male albino wistar rats were used in this study. Reference and working memory methods of Morris Water Maze (MWM) were used. Following behavioral testing, animals were decapitated under diethyl ether anesthesia. Brains were removed and fixed for 2 weeks for histological assessment. Finally, 7 μm thick coronal slices were cut and stained with PTAH staining for showing the astrocytes. Results: Our results showed a significant difference in the number of astrocytes between the control, reference and working memory groups. On the other hand, the number of astrocytes in the working memory group was more than the other groups. There was no difference in density of astrocytes between the lateral and medial parts of the cerebellum in any group. It seems that the distribution of astrocytes in the lateral and medial parts of cerebellum is similar. Discussion: We concluded that spatial learning such as reference or working memory methods, can increase the number of astrocytes in the cerebellum and this increase is similar in the cerebellar cortex.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Basic Clin. Neurosci. [Field not mapped to EPrints] AD - Neuroscience Research Center, Department of Anatomy, Golestan University of Medical Sciences, Gorgon, Iran [Field not mapped to EPrints] AD - Cellular and Molecular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of physiology, Institute of Pasteur, Tehran, Iran [Field not mapped to EPrints] AD - Department of Anatomy, Golestan University of Medical Sciences, Gorgon, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Astrocytes, Cerebellum, Spatial learning, animal behavior, animal experiment, animal tissue, article, astrocyte, brain slice, cell density, cellular distribution, cerebellum, controlled study, histopathology, male, maze test, molecular model, nonhuman, rat, reference memory, spatial memory, working memory
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:01
Last Modified: 11 May 2015 17:00
URI: http://eprints.goums.ac.ir/id/eprint/1954

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