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Legg-Calvé-Perthes disease and the risk of injuries requiring hospitalization

Hailer, Y.D. and Montgomery, S. and Ekbom, A. and Nilsson, O. and Bahmanyar, S. (2012) Legg-Calvé-Perthes disease and the risk of injuries requiring hospitalization. Acta Orthopaedica, 83 (6). pp. 572-576. ISSN 17453674 (ISSN)

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Background and purpose Previous studies have suggested that Legg-Calvé-Perthes disease (LCPD) is associated with repetitive trauma, coagulation problems and anatomical abnormalities of the blood supply to the femoral head. The hypothesis that repetitive trauma can affect the blood supply of the femoral head, leading to LCPD, is supported by an animal model. For evidence of an increased risk of repetitive trauma, we investigated whether patients with LCPD have a higher risk for severe injuries requiring hospitalization. Patients and methods We identified 2579 patients with LCPD in Sweden during the period 1964-2005. 13,748 individuals without LCPD were randomly selected from the Swedish general population, matched by year of birth, sex and region (control group). Cox proportional hazard regression estimated the risks. Results Compared to the control group, patients with LCPD had a modestly raised hazard ratio (HR) of 1.2 (95% CI 1.1-1.3) for injury requiring hospitalization. The risks were slightly higher for soft tissue injuries (HR = 1.3, 95% CI:1.1-1.4) than for fractures (HR = 1.1, 95% CI: 1.0-1.3) and more pronounced among females. Compared to the control group, the higher risk for injury only applied to the lower extremities (HR = 1.2, 95% CI: 1.0-1.4) in patients with LCPD. Interpretation Patients with LCPD are vulnerable to injuries which could be interpreted as a marker of hyperactive behavior. It could also implicate that anatomical changes in the bone formation or blood supply of the femoral head - increasing its sensibility for trauma - contribute to the etiology of LCPD. © Copyright: ©Nordic Orthopaedic Federation.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Acta Orthop. [Field not mapped to EPrints] C2 - 23043293 [Field not mapped to EPrints] AD - Department of Orthopaedics, Uppsala University Hospital, Uppsala, Sweden [Field not mapped to EPrints] AD - Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden [Field not mapped to EPrints] AD - Clinical Epidemiology and Biostatistics Unit, �rebro University Hospital, �rebro University, �rebro, Sweden [Field not mapped to EPrints] AD - Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: article, controlled study, female, fracture, hospitalization, human, injury, leg injury, major clinical study, male, Perthes disease, population research, risk assessment, sex difference, soft tissue injury, Sweden, Adult, Age Distribution, Aged, Case-Control Studies, Confidence Intervals, Female, Fractures, Bone, Hospitalization, Humans, Incidence, Injury Severity Score, Legg-Calve-Perthes Disease, Male, Middle Aged, Prognosis, Proportional Hazards Models, Reference Values, Registries, Retrospective Studies, Risk Assessment, Sex Distribution, Soft Tissue Injuries, Sweden, Wounds and Injuries
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 08:44
Last Modified: 11 May 2015 15:56
URI: http://eprints.goums.ac.ir/id/eprint/1935

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