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The effect of adding gentamicin to contrast media for prevention of cholangitis after biliary stenting for non-calculous biliary obstruction, a randomized controlled trial

Norouzi, A. and Khatibian, M. and Afroogh, R. and Chaharmahali, M. and Sotoudehmanesh, R. (2013) The effect of adding gentamicin to contrast media for prevention of cholangitis after biliary stenting for non-calculous biliary obstruction, a randomized controlled trial. Indian Journal of Gastroenterology, 32 (1). pp. 18-21. ISSN 02548860 (ISSN)

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Abstract

Aim: Cholangitis is the most common infectious complication of ERCP. In vitro studies showed that addition of aminoglycosides to contrast medium was effective in reducing cholangitis but the results of clinical trials are conflicting. We studied the effect of adding gentamicin to contrast medium in reducing the rate of post-ERCP cholangitis in patients with non-calculous obstructive jaundice. Methods: All patients with non-calculous obstructive jaundice who underwent endoscopic biliary stenting at the Shariati Hospital, Tehran, between December 2009 and October 2010 were enrolled in the study. Gentamicin (10 mg) or distilled water was added to each 10 cc contrast medium during ERCP. Intravenous antibiotics were administered before and after the procedure in all patients. After ERCP and stent deployment, patients were followed for 72 h for symptoms and signs of cholangitis. Results: A total of 114 patients were eligible for the study. Of these, 57 patients were included in each group. Cholangiocarcinoma was the most prevalent diagnosis. The obstruction was relieved in all patients by stenting. Five patients in each group (8. 8 %) developed cholangitis. There was no significant difference in the incidence of cholangitis between the two groups (p = 1. 000). Conclusions: With adequate drainage of the obstructed biliary tract by proper stenting, adding gentamicin to contrast media had no significant effect on incidence of post-ERCP cholangitis. © 2012 Indian Society of Gastroenterology.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Indian J. Gastroenterol. [Field not mapped to EPrints] C2 - 23081843 [Field not mapped to EPrints] AD - Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Science, North Kargar Ave., Shariati hospital, 14117-13135 Tehran, Iran [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Gholestan Research Center of Gastroenterology and Hepatology, 3rd floor, Shahid Nabavi clinic, 4th Azar Alley, 5th Azar St, 49177-65181 Gorgan city, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Cholangiopancreatography, Cholangitis, Cholestasis, Endoscopic retrograde, Stents, ceftriaxone, contrast medium, gentamicin, meglumine, placebo, adult, aged, article, bile duct carcinoma, biliary stent, cholangitis, cholestasis, controlled study, double blind procedure, endoscopic retrograde cholangiopancreatography, endoscopic therapy, female, high risk patient, human, Iran, major clinical study, male, obstructive jaundice, randomized controlled trial, Aged, Anti-Bacterial Agents, Bile Ducts, Intrahepatic, Cholangiopancreatography, Endoscopic Retrograde, Cholangitis, Contrast Media, Drug Combinations, Female, Follow-Up Studies, Gentamicins, Humans, Jaundice, Obstructive, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Stents, Treatment Outcome
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:56
Last Modified: 10 May 2015 10:16
URI: http://eprints.goums.ac.ir/id/eprint/1929

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