Golestan University of Medical Sciences Repository

Ecstasy, anxiety and rat hippocampal astrocytes

Jahanshahi, M. and Nikmahzar, E.G. and Babakordi, F. and Khosravi, M. and Seid-Hosseini, F. (2013) Ecstasy, anxiety and rat hippocampal astrocytes. European Journal of Anatomy, 17 (1). pp. 23-28. ISSN 11364890 (ISSN)

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Abstract

Ecstasy (MDMA) is a popular drug a used recreationally with the rave culture and consumed in a high environment temperature. Repeated and prolonged MDMA ingestion is well known to cause depression, anxiety and aggression. The aim of this study was to evaluate the sub-chronic effects of MDMA on anxiety in Wistar rats and to determine astrocytes density in the rat hippocampus after anxiety. In this study, 28 adult male Wistar rats were used. The animals were distributed randomly in four groups, one sham group (receiving 1 ml/kg 0.9% saline solution) and three experimental groups: Exp. 1 (1.25 mg/kg/day MDMA), Exp. 2 (2.5 mg/kg/day MDMA), and Exp. 3 (5 mg/kg/day MDMA). The animals received Saline or MDMA for a week (sub-chronic period). An Elevated Plus Maze apparatus was used to examine anxiety levels in the rats. 24 h. after the last injection and behavioral test, the rat brains were withdrawn and fixed with 4% paraformaldehyde, and then - after histological processing - the slices of hippocampus were stained with PTAH for astrocytes. Our results showed that MDMA at 2.5 mg/kg/day for a week was most effective in causing anxiety. We found that the number of astrocytes was increased after this period. The greatest increase in astrocyte numbers was observed in the dentate gyrus of the5 mg/kg MDMA group. We concluded that the administration of MDMA over 7 days (sub-chronic period) can cause anxiety and can have an effect on the astrocyte density of the rat hippocampus.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Eur. J. Anat. [Field not mapped to EPrints] AD - Department of Anatomy, Neuroscience Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Anxiety, Astrocyte, Ecstasy, Hippocampus, Rat, 3,4 methylenedioxymethamphetamine, paraformaldehyde, animal cell, animal experiment, animal model, animal tissue, anxiety, article, astrocyte, behavior, controlled study, dentate gyrus, hippocampus, histology, male, maze test, memory, nerve cell, nonhuman, rat
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 04:02
Last Modified: 15 Jun 2015 05:12
URI: http://eprints.goums.ac.ir/id/eprint/1928

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