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Mucocutaneous manifestations and nail changes in patients with end-stage renal disease on hemodialysis.

Tajbakhsh, R. and Dehghan, M. and Azarhoosh, R. and Haghighi, A.N. and Sadani, S. and Zadeh, S.S. and Kabootari, M. and Qorbani, M. (2013) Mucocutaneous manifestations and nail changes in patients with end-stage renal disease on hemodialysis. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24 (1). pp. 36-40. ISSN 13192442 (ISSN)

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Mucocutaneous manifestations are common among patients on hemodialysis (HD). This study was undertaken to determine the prevalence of mucocutaneous manifestations in patients with end-stage renal disease (ESRD) who are on HD. In this cross-sectional, descriptive and analytic study conducted in 2009, 100 patients on HD at the Five Azar Hospital in Gorgan city were randomly selected. All the patients underwent detailed examination by a dermatologist to look for lesions in the skin, hair, nail and mucous membranes; if felt necessary, biopsy was obtained from the lesions. The findings were statistically analyzed using SPSS-13 software. For evaluation of normality of distribution, Kolmogorov-Smirnov was used, for quantitative variables Mann-Whitney and T-test (abnormal distribution) were used and for qualitative variables, Chi-2 and Fisher were used. In this study, P-value less than 0.05 was considered significant. Fifty-one males and 49 females were enrolled. The mean age was 49 ± 12 years. Diabetes was the most common cause of ESRD. In 95% of the patients, at least one mucocutaneous manifestation was present. Xerosis (78.3%) was the most common lesion, followed by pruritus (39.1%), lentigo (34.8%), skin discoloration (32.6%), leukonychia (32%) and thinning of the nail bed (24%). Xerosis, scaling, lentigo, folliculitis, idiopathic guttate hypopigmentation, leukonychia and half and half nail were associated with age. A significant relationship was seen between duration on dialysis and skin discoloration and leukonychia. Clubbing had a significant association with calcium-phosphorus product (Ca � P). There was a significant association between serum ferritin level and pruritus and tinea versicolor lesions. Our study shows that mucocutaneous manifestations are common among patients with ESRD. Identification of these manifestations and their association with causative factors are useful for preventing the lesions.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Saudi J Kidney Dis Transpl [Field not mapped to EPrints] C2 - 23354189 [Field not mapped to EPrints] AD - Department of Nephrology, Golestan University of Medical Sciences, Gorgan, Iran. [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: age, article, biopsy, chronic kidney failure, comparative study, cross-sectional study, female, follow up, human, Iran, male, middle aged, nail, nail disease, pathology, prevalence, pruritus, renal replacement therapy, risk factor, sex difference, skin, skin disease, Age Factors, Biopsy, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Iran, Kidney Failure, Chronic, Male, Middle Aged, Nail Diseases, Nails, Prevalence, Pruritus, Renal Dialysis, Risk Factors, Sex Factors, Skin, Skin Diseases
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 06:19
Last Modified: 11 May 2015 05:11
URI: http://eprints.goums.ac.ir/id/eprint/1927

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