Golestan University of Medical Sciences Repository

Lack of association between TRAF1/C5 rs10818488 polymorphism and rheumatoid arthritis in Iranian population

Samadian, E. and Bidmeshkipour, A. and Gharaei, R. and Soleymani-Nejadian, E. and Shirkavand, A. (2013) Lack of association between TRAF1/C5 rs10818488 polymorphism and rheumatoid arthritis in Iranian population. Egyptian Journal of Medical Human Genetics, 14 (1). pp. 63-67. ISSN 11108630 (ISSN)

[img]
Preview
PDF - Published Version
Download (356kB) | Preview

Abstract

Rheumatoid arthritis (RA) is a multifactorial disorder related to the inflammatory response system with debilitating and painful conditions. Both genetic and environmental factors, with unknown etiology, play important roles in this disease pathogenesis. Recently, TRAF1/C5 (Tumor Necrosis Factor Receptor-Associated Factor 1/. Complement Component 5) polymorphism associated with increased risk for RA has been studied in different populations worldwide, and inconsistent results have been obtained. rs10818488 allele is located on TRAF1/C5 intergenic region, and has been predicted to be functional. A total of 100 sex- and age-matched people including RA patients (n= 50) and healthy individuals (n= 50) from Iran have been entered in this study and genotyped for rs10818488 (A/G) polymorphism, using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). In our study, rs10818488 allele was not associated with risk for RA in Iranian population (p>. 0.05, OR = 1.27, 95% CI = 0.72-2.23). Results revealed that this allele might be population-specific and not to be associated with their corresponding gene pool. However, further analyses are required to clarify other RA-associated markers in our community. © 2012.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Egypt. J. Med. Hum. Genet. [Field not mapped to EPrints] AD - Department of Molecular Medicine, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Golestan, Iran [Field not mapped to EPrints] AD - Department of Cell and Molecular Biology, Faculty of Science, Razi University, Kermanshah, Iran [Field not mapped to EPrints] AD - Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, India [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Iranian population, Rheumatoid arthritis, TRAF1/C5 rs10818488 polymorphism, complement component C5, tumor necrosis factor receptor associated factor 1, allele, article, clinical article, controlled study, female, gene pool, genetic association, genotype, human, Iran, male, polymerase chain reaction, restriction fragment length polymorphism, rheumatoid arthritis, risk, single nucleotide polymorphism
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 03:54
Last Modified: 10 May 2015 16:19
URI: http://eprints.goums.ac.ir/id/eprint/1921

Actions (login required)

View Item View Item