Lack of association between TRAF1/C5 rs10818488 polymorphism and rheumatoid arthritis in Iranian population

Samadian, E. and Bidmeshkipour, A. and Gharaei, R. and Soleymani-Nejadian, E. and Shirkavand, A. (2013) Lack of association between TRAF1/C5 rs10818488 polymorphism and rheumatoid arthritis in Iranian population. Egyptian Journal of Medical Human Genetics, 14 (1). pp. 63-67. ISSN 11108630 (ISSN)

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Abstract

Rheumatoid arthritis (RA) is a multifactorial disorder related to the inflammatory response system with debilitating and painful conditions. Both genetic and environmental factors, with unknown etiology, play important roles in this disease pathogenesis. Recently, TRAF1/C5 (Tumor Necrosis Factor Receptor-Associated Factor 1/. Complement Component 5) polymorphism associated with increased risk for RA has been studied in different populations worldwide, and inconsistent results have been obtained. rs10818488 allele is located on TRAF1/C5 intergenic region, and has been predicted to be functional. A total of 100 sex- and age-matched people including RA patients (n= 50) and healthy individuals (n= 50) from Iran have been entered in this study and genotyped for rs10818488 (A/G) polymorphism, using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). In our study, rs10818488 allele was not associated with risk for RA in Iranian population (p>. 0.05, OR = 1.27, 95% CI = 0.72-2.23). Results revealed that this allele might be population-specific and not to be associated with their corresponding gene pool. However, further analyses are required to clarify other RA-associated markers in our community. © 2012.

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