Khori, V. and Alizadeh, A.M. and Nikyar, B. and Banikarimi, A. and Badaghabadi, F. and Soltani, A. and Nayebpour, M. (2013) Modulation of extracellular atrioventricular node field potential pattern and ventricular rhythm by morphine in experimental atrial fibrillation in isolated rabbit heart. Physiology and Pharmacology, 17 (1). pp. 27-38. ISSN 17350581 (ISSN)
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Abstract
Introduction: Endorphins are produced by cardiomyocytes, and exert different effects on the heart. The aim of the present study is to assess morphine effects on extracellular atrioventricular (AV) node field potential pattern and ventricular rhythm of isolated rabbit heart during experimental atrial fibrillation (AF). Methods: Effects of different concentrations of morphine (10, 20, 50 and 100 μM) were assessed by applying basic stimuli protocols involving Wenckebach, recovery, zone of concealment and concealed conduction parameters during experimental atrial fibrillation in isolated rabbit heart. Two-way ANOVA was used to compare the groups. Results: Morphine significantly suppressed basic parameters of AV node. Morphine (100 μM) significantly increased wenckebach index (153.6±3.9 to 169.8±2.9 ms) and functional refractory period (156.9±3.0 to 176.4±3.5 ms) (P<0.05). During experimental atrial fibrillation, morphine nonsignificantly increased mean His-His interval, concealed conduction and zone of concealment (P > 0.05). Conclusion: The present results showed that morphine has concentration-dependent effects on AV node electrophysiological properties. Morphine at low concentrations can decrease nodal conduction and refractoriness of AV node, but in high concentrations causes increased nodal conduction without concealed conduction changes. Dual effects of morphine can explain the unpredictable behavior of heart in cardiac tachyarrhythmias.
| Item Type: | Article |
|---|---|
| Additional Information: | Unmapped bibliographic data: LA - Persian [Field not mapped to EPrints] J2 - Physiol. Pharmacol. [Field not mapped to EPrints] AD - Golestan Cardiovascular Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Health Information Management Center, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Dept. of Toxicology, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] |
| Uncontrolled Keywords: | Atrial fibrillation, Atrioventricular node, Eelectrophysiology, Morphine, morphine, animal tissue, article, cardiovascular parameters, electrical potential parameters, heart atrioventricular node, heart atrium fibrillation, heart muscle refractory period, heart rhythm, His His interval, nodal conduction, nonhuman, rabbit, wenckebach index |
| Subjects: | مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus موارد کلی |
| Divisions: | معاونت تحقیقات و فناوری |
| Depositing User: | GOUMS |
| Date Deposited: | 20 Apr 2015 06:04 |
| Last Modified: | 24 Oct 2016 08:19 |
| URI: | http://eprints.goums.ac.ir/id/eprint/1920 |
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