Golestan University of Medical Sciences Repository

Placental weight and mortality in premenopausal breast cancer by tumor characteristics

Hajiebrahimi, M.H. and Bahmanyar, S. and Lambe, M. and Adolfsson, J. and Fornander, T. and Wärnberg, F. and Cnattingius, S. (2013) Placental weight and mortality in premenopausal breast cancer by tumor characteristics. Breast Cancer Research and Treatment, 137 (1). pp. 297-305. ISSN 01676806 (ISSN)

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Abstract

Placental weight may be regarded as an indirect marker of hormone exposures during pregnancy. There is epidemiological evidence that breast cancer mortality in premenopausal women increases with placental weight in the most recent pregnancy. We investigated if this association differs by tumor characteristics, including expression of estrogen and progesterone receptors. In a Swedish population-based cohort, we followed 1,067 women with premenopausal breast cancer diagnosed from 1992 to 2006. Using Cox regression models, we estimated hazard ratios for the association between placental weight and risk of premenopausal breast cancer mortality. In stratified analyses, we estimated mortality risks in subjects with different tumor stages, estrogen receptor (ER) or progesterone receptor (PR) status. Compared with women with placental weight less than 600 g, women with a placental weight between 600 and 699 g were at a 50 % increased risk of mortality, however, not significant change in risk was observed for women with placental weight �700 g. Mortality risks associated with higher placental weight were more pronounced among ER- and PR- breast cancer tumors, where both a placental weight 600-699 g and �700 g were associated with a more than doubled mortality risks compared with tumors among women with placental weight less than 600 g. Moreover, stratified analyses for joint receptor status revealed that a consistent increased mortality risk by placental weight was only apparent in women with ER-/PR- breast cancer. The increased mortality risk in premenopausal breast cancer associated with higher placental weight was most pronounced among ER- and PR- tumors. © 2012 Springer Science+Business Media New York.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Breast Cancer Res. Treat. [Field not mapped to EPrints] C2 - 23149466 [Field not mapped to EPrints] AD - Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden [Field not mapped to EPrints] AD - Center for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Regional Cancer Center, Uppsala, Sweden [Field not mapped to EPrints] AD - Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden [Field not mapped to EPrints] AD - Department of Surgical Science, Uppsala University, Uppsala, Sweden [Field not mapped to EPrints] AD - Faculty of Public Health, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Breast cancer, Estrogen receptor, Placental weight, Premenopausal, Progesterone receptor, estrogen receptor, progesterone receptor, adult, article, breast cancer, cancer mortality, cancer staging, cohort analysis, controlled study, disease association, female, human, major clinical study, placenta weight, pregnancy outcome, premenopause, priority journal, protein expression, risk assessment, risk factor, Sweden, tumor differentiation, Adult, Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Female, Humans, Middle Aged, Organ Size, Placenta, Pregnancy, Premenopause, Proportional Hazards Models, Prospective Studies, Receptors, Estrogen, Receptors, Progesterone, Risk, Sweden
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:12
Last Modified: 10 May 2015 05:37
URI: http://eprints.goums.ac.ir/id/eprint/1917

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