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Obesity and risk of hypercholesterolemia in Iranian northern adults

Veghari, G. and Sedaghat, M. and Joshghani, H. and Banihashem, S. and Moharloei, P. and Angizeh, A. and Tazik, E. and Moghaddami, A. (2013) Obesity and risk of hypercholesterolemia in Iranian northern adults. ARYA Atherosclerosis, 9 (1). ISSN 17353955 (ISSN)

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Abstract

BACKGROUND: The main aim of this study was to evaluate the association between serum cholesterol level and body mass index (BMI) in northern Iran. METHODS: This was a cross-sectional study carried out on the 1995 subjects (997 males and 998 females) aged 25-65 years that were selected using multistage cluster sampling method. Plasma cholesterol was measured in the morning after a 12-hour fasting and was determined by auto-analyzer. Hypercholesterolemia (HC) was defined by a total plasma cholesterol level over 200 mg/dl. Weight and height were measured and BMI 25-29.9 kg/m2 and ≥ 30 kg/m2 was classified overweight and obesity, respectively. RESULTS: Mean of age was 44.2 ± 11.5 years (44.3 ± 11.5 in men and 44.1 ± 11.2 in women) and plasma total cholesterol level was 203.1 ± 41.8 mg/dl. The HC was detected in 49.1% with higher rate in women (57.0%) than men (44.7%). In men at age 25-35 years, the odds ratio was 3.42 (1.60-7.29) in obese group and 1.90 (1.03-3.50) in overweight group compared to normal weight. In women, at age 35-45 years, the risk of HC in obese group was 3.01 (1.58-5.73) and in overweight group it was 2.06 (1.58-5.73), while in men aged 35-45 years the relative risk was 4.03 (2.22-7.34) in overweight and 3.58 (1.77-7.25) in obese group. In women after age 45 years, higher BMI was not a risk factor for HC. CONCLUSION: There was a positive association between BMI and serum cholesterol level. In early middle age, obese individuals were at risk of HC more than overweight subjects. In men, after age 35 years, the risk of HC increased in overweight group while in women there was no statistically significant association between BMI and HC.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Arya Atheroscler. [Field not mapped to EPrints] AD - Ischemic Disorders Research Center, School of Medicine, Golestan University of Medical Sciences, Golestan, Iran [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Golestan, Iran [Field not mapped to EPrints] AD - Department of Clinical Biochemistry, Golestan University of Medical Sciences, Golestan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Adult, Body mass index, Gender, Iran, Serum cholesterol level, cholesterol, adult, age, aged, article, body height, body mass, body weight, cross-sectional study, disease association, female, gender, human, hypercholesterolemia, male, obesity, risk
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 09:09
Last Modified: 17 Jan 2017 10:10
URI: http://eprints.goums.ac.ir/id/eprint/1914

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