Golestan University of Medical Sciences Repository

The effects of modified alternate-day fasting diet on weight loss and CAD risk factors in overweight and obese women

Eshghinia, S. and Mohammadzadeh, F. (2013) The effects of modified alternate-day fasting diet on weight loss and CAD risk factors in overweight and obese women. Journal of Diabetes and Metabolic Disorders, 12 (1). ISSN 22516581 (ISSN)

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Abstract

Background: Obesity is a worldwide health problem with increasing prevalence. Decrease in energy intake has been shown to lower the risk of coronary artery disease in obese subjects. The common form of dietary restriction is daily calorie restriction (CR). Another form is alternate-day fasting (ADF). This study examined the ability of modified ADF to facilitate weight loss and lower cardiovascular risk factors in overweight and obese women.Methods: 15 adult subjects completed an 8 weeks trial (2 weeks observed and 6 weeks ADF). All women consumed very low calorie diet on the fast day and usually diet in every other day. Body weight (BW), fat mass and blood pressure (BP) were measured. Fasting blood samples were collected at the first and 57th day of trial for biochemical analysis.Results: During the course of the trial, BW of the subjects decreased (p < 0/0001) from 84/3 ± 11/44 kg to 78/3 ± 10/18 kg. Waist Circumference decreased from 87/87 ± 9/74 to 82/86 ± 9/68(p < 0/001). Reduction in systolic BP was seen from 114.8 ± 9.16 to 105.13 ± 10.19 mmHg (p < 0/001) and diastolic BP changed from 82.86 ± 10.6 to 74.5 ± 10.8 (P < 0.05). Total cholesterol decreased from 227/73 ± 49/96 to 214/67 ± 43/27, TG from 160/5 ± 46/18 to 143/9 ± 22/77, LDL from 149/46 ± 49/81 to 131/3 ± 50/97, and FBS from 102 ± 14/7 to 96 ± 11/79 mg/dl but were not significant. HDL increased from 42/32 ± 18/01 to 50/58 ± 19/46 and was not significant.Conclusion: These finding suggest that short time ADF is a viable dietary option to help obese individuals lose weight and decrease some CAD risk factors. More and longer-term studies in human subjects are needed to support this important result. © 2013 Eshghinia and Mohammadzade; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - 4 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - J. Diabetes Metabolic Disord. [Field not mapped to EPrints] AD - Biochemistry and Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Internal medicine, 5th Azar University Hospital, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Alternate-day fasting, Serum lipids, Weight loss, cholesterol, high density lipoprotein, low density lipoprotein, triacylglycerol, glucose, high density lipoprotein cholesterol, low density lipoprotein cholesterol, adult, article, body weight, cardiovascular risk, cholesterol blood level, clinical article, coronary artery disease, diastolic blood pressure, diet restriction, fat mass, female, glucose blood level, human, low calory diet, obesity, risk reduction, systolic blood pressure, therapy effect, triacylglycerol blood level, waist circumference, weight reduction, alternate day fasting, Article, blood pressure measurement, blood pressure regulation, blood sampling, cardiovascular risk, coronary artery disease, middle aged, outcome assessment, weight reduction, young adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 19 Apr 2015 05:39
Last Modified: 10 May 2015 04:31
URI: http://eprints.goums.ac.ir/id/eprint/1912

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