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Estimating the avoidable burden of certain modifiable risk factors in osteoporotic hip fracture using Generalized Impact Fraction (GIF) model in Iran

Shahnazari, B. and Keshtkar, A. and Soltani, A. and Aghamaleki, A. and Mansour, A. and Matin, B. and Saghafi, S. and Dini, M. and Khashayar, P. and Larijani, B. (2013) Estimating the avoidable burden of certain modifiable risk factors in osteoporotic hip fracture using Generalized Impact Fraction (GIF) model in Iran. Journal of Diabetes and Metabolic Disorders, 12 (1). ISSN 22516581 (ISSN)

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Abstract

Backgrounds: The number of hip fractures, the most common complication of osteoporosis, has increased rapidly over the past decades. The goal of this study is to estimate the avoidable burden of certain modifiable risk factor of the condition using the Generalized Impact Fraction (GIF) model, which has been suggested and used by epidemiologists to overcome the drawbacks associated with the use of Attributable Fraction index. In addition to preventing a risk factor or the avoidable fraction of burden, this index can also calculate the change in the burden, when a risk factor is altered.Methods: International databases were searched through PubMed, CINAHLD, Embase using OVID and Google scholar. National resources were searched through IranDoc, IranMedex, SID and Journal sites. Other resources include abstract books and articles sent to the IOF congress. The following search strategy was used: (" Osteoporotic fracture" OR " Fragility Hip fracture" OR " Calcium" OR " vitamin D" OR " BMI" OR " lean body weight" OR " Physical activity" OR " exercise" OR " Smoke" ) AND (" prevalence" OR " incidence" OR " relative risk" ) and limited to " humans." Results: With regards to different scenarios already explained in modifying the studied risk factors, the greatest impact in reducing the prevalence of risk factors on osteoporotic hip fractures, was seen in low serum vitamin D levels, low physical activity and low intake of calcium and vitamin D, respectively. According to the fact that interventions for low serum vitamin D and low intake of calcium and vitamin D, are related to each other, it can be concluded that implementing interventions to change these two risk factors, in the easy, moderate and difficult scenarios, would result in approximately a 5%, 11% and 17% decrease in the burden of osteoporotic hip fractures, respectively. The addition of interventions addressing low physical activity in the easy, moderate and difficult scenarios, an 8%, 21% and 35% reduction in the burden of osteoporotic hip fractures would be reported, respectively.Conclusion: Improving serum vitamin D levels, recommending the consumption of calcium and vitamin D supplementations and advocating physical activity are the most effective interventions to reduce the risk of osteoporotic hip fractures. © 2013 Shahnazari et al; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: C7 - 10 [EPrints field already has value set] LA - English [Field not mapped to EPrints] J2 - J. Diabetes Metabolic Disord. [Field not mapped to EPrints] AD - Osteoporosis Research Center (ORC), Endocrinology and Metabolism Clinical Sciences Research Institute (ECSI), Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Endocrinology and Metabolism Research Center (EMRC), Endocrinology and Metabolism Clinical Sciences Research Institute (ECSI), Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Psychiatry, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Musculoskeletal Disease Office, Non-communicable Disease Committee, Iranian Ministry of Health and Medical Education, Tehran, Iran [Field not mapped to EPrints] AD - EMRC, Shariati Hospital, Kargar St, Tehran 1411413137, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: BMI, Calcium, Fragility hip fracture, Incidence, Osteoporotic fracture, Physical activity, Prevalence, Smoke, Vitamin D, calcium, vitamin D, calcium, vitamin D, article, body mass, body weight, calcium intake, exercise, Generalized Impact Fraction model, hip fracture, human, Iran, morbidity, osteoporosis, physical activity, prevalence, risk factor, smoking, statistical model, vitamin blood level, vitamin intake, Article, calcium blood level, clinical assessment tool, fragility fracture, Generalized Impact Fraction, hip fracture, meta analysis (topic), osteoporotic hip fracture, osteoporotic hip fracture, risk assessment, risk reduction, systematic review (topic), vitamin supplementation
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2015 09:34
Last Modified: 11 May 2015 04:30
URI: http://eprints.goums.ac.ir/id/eprint/1909

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