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Penbactam for Helicobacter pylori eradication: A randomised comparison of quadruple and triple treatment schedules in an Iranian population

Seyedmajidi, S. and Mirsattari, D. and Zojaji, H. and Zanganeh, E. and Seyyedmajidi, M. and Almasi, S. and Zali, M. (2013) Penbactam for Helicobacter pylori eradication: A randomised comparison of quadruple and triple treatment schedules in an Iranian population. Arab Journal of Gastroenterology, 14 (1). pp. 1-5. ISSN 16871979 (ISSN)

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Abstract

Background & study aims: Selection of the best drug regimens for eradication of Helicobacter pylori infection especially in patients at risk of peptic ulcer relapses and the development of complications is challenging. This study assessed and compared the efficacy of the two common PPI based triple therapies to a quadruple therapy including PPI, metronidazole, amoxicillin and a bismuth compound in Iranian population. Patients & Methods: Three hundred and thirty patients with peptic ulcer and H. pylori infection were included in the study. Patients were randomly assigned to one of the three treatment protocols all given twice daily: (a) A 14-day quadruple therapy (OMAB group) comprising omeprazole 20. mg, metronicazole 500. mg, amoxicillin 1. g, and bismuth subcitrate 240. mg; (b) A 14-day triple regimen (OCP group) comprising omeprazole 20. mg plus clarithromycine 500. mg and penbactam 750. mg and (c) A 14-day triple regimen (OCA group) comprising omeprazole 20. mg plus clarithromycine 500. mg and amoxicillin 1. g. Cure was defined as a negative urea breath test at least six weeks after treatment. Results: The per-protocol eradication rates achieved with both OCP regimen (87.0%) and OCA treatment (90.8%) were significantly higher than the OMAB treatment protocol (56.0%); however, no significant difference emerged in eradication rates between the two triple treatment schedules. No significant differences between the groups were found in most side-effects. Conclusion: Two-week quadruple therapy showed a lower eradication rate compared to common triple treatment schedules when used as first-line eradication treatment for H. pylori infection in Iranian population. © 2012 Arab Journal of Gastroenterology.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Arab J. Gastroenterol. [Field not mapped to EPrints] C2 - 23622801 [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Department of Internal Medicine, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Research Center for Gastroenterology and Liver Disease, Department of Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of IT Engineering, Khajenasir Toosi University of Technology, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Helicobacter pylori, Penbactam, Treatment, amoxicillin, antibiotic agent, bismuth citrate, clarithromycin, metronidazole, omeprazole, penbactam, unclassified drug, urea c 13, abdominal pain, abnormal feces, adult, aged, antibiotic therapy, article, combination chemotherapy, controlled study, coughing, diarrhea, dizziness, double blind procedure, drug efficacy, drug induced headache, dyspepsia, eradication therapy, feces, female, Helicobacter infection, Helicobacter pylori, human, Iran, major clinical study, male, nausea, peptic ulcer, priority journal, prospective study, randomized controlled trial, taste disorder, urea breath test, Adolescent, Adult, Aged, Aged, 80 and over, Amoxicillin, Ampicillin, Analysis of Variance, Anti-Bacterial Agents, Anti-Ulcer Agents, Breath Tests, Clarithromycin, Drug Combinations, Drug Therapy, Combination, Female, Helicobacter Infections, Helicobacter pylori, Humans, Iran, Male, Metronidazole, Middle Aged, Omeprazole, Organometallic Compounds, Peptic Ulcer, Proton Pump Inhibitors, Sulbactam, Urea, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 08:57
Last Modified: 11 May 2015 04:20
URI: http://eprints.goums.ac.ir/id/eprint/1906

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