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Effects of repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) on avoidance memory and cell density in rats' hippocampus

Jahanshahi, M. and Haidari, K. and Mahaki-Zadeh, S. and Nikmahzar, E.G. and Babakordi, F. (2013) Effects of repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) on avoidance memory and cell density in rats' hippocampus. Basic and Clinical Neuroscience, 4 (1). pp. 57-63. ISSN 2008126X (ISSN)

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Abstract

Introduction: MDMA or ecstasy is a derivative of amphetamines used mostly by young people worldwide. Although the acute effects of this drug are known, the effect of chronic administration is not well studied. Therefor the aim of this study was to determine the effects of repeated (long term) administration of MDMA on rats' memory and their hippocampal cell density. Method: Young adult male Wistar rats 200 ± 20 g served as subjects. The rats were randomly distributed into three MDMA treated groups (3�2.5 mg/kg, 3�5 mg/kg, 3�10 mg/kg) and one control-saline group. All animals received MDMA intraperitoneally (3h apart; a challenge) 7th day of every week for consecutive 4 weeks. Animals were trained before and were tested after injections for their memory status using the standards passive avoidance method. Finally, 24hr after the memory test, rats were sacrificed and after tissue operations, the hippocampal astrocytes and neurons were counted. Results: results showed that the number of neurons in all experimental groups was lower than the control-saline group. The most decreased number of neurons was shown in 5 mg/kg MDMA group compared to control-saline in all the regions of hippocampus. Also we found that repeated administration of MDMA reduced the number of hippocampal astrocytes. Discussion: It is concluded that repeated administration of MDMA can reduce density of neurons and astrocytes and this decrease is not dose dependence.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Basic Clin. Neurosci. [Field not mapped to EPrints] AD - Neuroscience Research Center, Department of Anatomy, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Astrocytes, Ecstasy, Neurons, Passive avoidance memory, 3,4 methylenedioxymethamphetamine, animal behavior, animal cell, animal experiment, animal model, animal tissue, article, astrocyte, avoidance behavior, brain cell, brain region, cell density, cell loss, chronic drug administration, controlled study, experimental rat, hippocampus, male, memory disorder, neurologic examination, neurotoxicity, nonhuman, passive avoidance, rat, repeated drug dose, tissue distribution, toxicity testing, toxicokinetics
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:00
Last Modified: 10 May 2015 06:10
URI: http://eprints.goums.ac.ir/id/eprint/1902

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