Golestan University of Medical Sciences Repository

Association of tooth loss and oral hygiene with risk of gastric adenocarcinoma

Shakeri, R. and Malekzadeh, R. and Etemadi, A. and Nasrollahzadeh, D. and Abedi-Ardekani, B. and Khoshnia, M. and Islami, F. and Pourshams, A. and Pawlita, M. and Boffetta, P. and Dawsey, S.M. and Kamangar, F. and Abnet, C.C. (2013) Association of tooth loss and oral hygiene with risk of gastric adenocarcinoma. Cancer Prevention Research, 6 (5). pp. 477-482. ISSN 19406207 (ISSN)

[img] PDF - Published Version
Restricted to Repository staff only

Download (202kB)


Poor oral health and tooth loss have been proposed as possible risk factors for some chronic diseases, including gastric cancer. However, a small number of studies have tested these associations. We conducted a case-control study in Golestan Province, Iran, that enrolled 309 cases diagnosed with gastric adenocarcinoma (118 noncardia, 161 cardia, and 30 mixed-locations) and 613 sex, age, and neighborhood matched controls. Data on oral health were obtained through physical examination and questionnaire including tooth loss, the number of decayed, missing, and filled teeth, and frequency of tooth brushing. ORs and 95% confidence intervals (95% CI) were obtained using conditional logistic regression models adjusted for potential confounders. Standard one degree-of-freedom linear trend test and a multiple degree-of-freedom global test of the effect of adding oral hygiene variables to the model were also calculated. Our results showed apparent associations between tooth loss and decayed, missing, filled teeth (DMFT) score with risk of gastric cancer, overall and at each anatomic subsite. However, these associations were not monotonic and were strongly confounded by age. The results also showed that subjects who brushed their teeth less than daily were at significantly higher risk for gastric cardia adenocarcinoma ORs (95% CI) of 5.6 (1.6-19.3). We found evidence for an association between oral health and gastric cancer, but the nonmonotonic association, the relatively strong effect of confounder adjustment, and inconsistent results across studies must temper the strength of any conclusions. © 2013 AACR.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Cancer Prev. Res. [Field not mapped to EPrints] C2 - 23503651 [Field not mapped to EPrints] AD - Department of Medicine, Digestive Disease Research Centre, Tehran University of Medical Sciences, 1411713135, Tehran, Iran [Field not mapped to EPrints] AD - Investigator, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States [Field not mapped to EPrints] AD - Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden [Field not mapped to EPrints] AD - International Agency for Research on Cancer (IARC), Lyon, France [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, NY, United States [Field not mapped to EPrints] AD - Genome Modifications and Carcinogenesis Division, Infection and Cancer Program, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany [Field not mapped to EPrints] AD - Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, MD, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: adult, aged, article, cancer risk, case control study, cohort analysis, controlled study, dental caries, disease association, female, human, Iran, major clinical study, male, mouth hygiene, periodontal disease, physical examination, priority journal, questionnaire, stomach adenocarcinoma, tooth filling, toothbrush, Adenocarcinoma, Adult, Aged, Case-Control Studies, Dentition, Female, Follow-Up Studies, Helicobacter Infections, Helicobacter pylori, Humans, Male, Middle Aged, Oral Health, Oral Hygiene, Prognosis, Stomach Neoplasms, Tooth Loss
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:15
Last Modified: 26 Feb 2018 07:11
URI: http://eprints.goums.ac.ir/id/eprint/1892

Actions (login required)

View Item View Item