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Marked increase in the incidence rate of esophageal adenocarcinoma in a high-risk area for esophageal cancer

Ghasemi-Kebria, F. and Roshandel, G. and Semnani, S. and Shakeri, R. and Khoshnia, M. and Naeimi-Tabiei, M. and Merat, S. and Malekzadeh, R. (2013) Marked increase in the incidence rate of esophageal adenocarcinoma in a high-risk area for esophageal cancer. Archives of Iranian Medicine, 16 (6). pp. 320-323. ISSN 10292977 (ISSN)

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Abstract

BACKGROUND: Esophageal cancer (EC) is the eighth common cancer worldwide. Esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAD) are the most common histologic types of EC. Many recent reports showed an increasing trend in EAD and a decreasing trend in ESCC in many Western countries. Golestan Province in northeastern Iran has been known as a high-risk area for EC. The aim of this study was to describe the time trend of EAD in this area between 2000-2009. METHODS: Data on cancer cases were obtained from Golestan Population-based Cancer Registry. Analysis was done using Joinpoint software. To examine the incidence trends, the annual percent change was calculated. The possibilities of anatomic and histologic misclassification were considered by assessing the trend of ESCC and gastric adenocarcinoma. RESULTS: A total number of 1186 histologically-confirmed EC cases were recruited. The incidence rate of EAD showed a significant increasing trend. There was no significant trend in the incidence of ESCC during the study period. A significant increase in the incidence rate of gastric adenocarcinoma was observed during the period of 2000-2005, followed by a plateau during the period of 2005-2009. CONCLUSIONS: We found a significant increasing trend in the incidence rate of EAD. We find no evidence to support an alternative explanation including anatomic and histologic misclassification. So, the observed rise in the incidence of EAD seems to be real. Therefore, designing and implementation of control programs, including control of preventable risk factors of EAD, should be considered in this high- risk area.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Arch. Iran. Med. [Field not mapped to EPrints] C2 - 23725063 [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Adenocarcinoma, Epidemiology, Esophagus, Golestan, Iran, article, cancer classification, cancer incidence, cancer registry, esophageal adenocarcinoma, esophageal squamous cell carcinoma, female, high risk population, histology, human, Iran, major clinical study, male, stomach adenocarcinoma, trend study, Adenocarcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms, Female, Humans, Incidence, Iran, Male, Registries, Risk Factors
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 09:05
Last Modified: 10 May 2015 04:59
URI: http://eprints.goums.ac.ir/id/eprint/1878

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