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Effect of Helicobacter pylori eradication on glycaemia control in patients with type 2 diabetes mellitus and comparison of two therapeutic regimens

Vafaeimanesh, J. and Rajabzadeh, R. and Ahmadi, A. and Moshtaghi, M. and Banikarim, S. and Hajiebrahimi, S. and Seyyedmajidi, M. (2013) Effect of Helicobacter pylori eradication on glycaemia control in patients with type 2 diabetes mellitus and comparison of two therapeutic regimens. Arab Journal of Gastroenterology, 14 (2). pp. 55-58. ISSN 16871979 (ISSN)

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Abstract

Background and study aims: The eradication rate of Helicobacter pylori (H. pylori) has been reported as being lower in patients with type 2 diabetes mellitus (DM) than in those without DM. The aim of the study was to assess the efficacy of the two H. pylori eradication regimens in patients without and with type 2 DM and to study the effect of H. pylori treatment on glycaemia control. Patients and Methods: A total of 93 consecutive type 2 DM (non-insulin users) and 98 non-diabetic age- and sex-matched patients were enrolled. Patients were randomly assigned to one of the two treatment protocols all given twice daily: (a) a 14-day quadruple therapy comprising of omeprazole 20mg, metronidazole 500mg, amoxicillin 1g and bismuth subcitrate 240mg (OMAB) and (b) a 14-day triple regimen comprising of omeprazole 20mg plus clarithromycin 500mg and amoxicillin 1g (OCA). Cure was defined as a negative 13C-urea breath test at least 6weeks after treatment. Results: The H. pylori eradication rate with the OCA regimen was 63% in patients with type 2 DM (non-insulin users) and 87.7% in the control group (p=0.017). The H. pylori eradication rate with the OMAB regimen was 38.2% in patients with type 2 DM and 55.1% in the control group (p<0.001). Mean decrease of fasting plasma glucose and HbA1c level shows no statistically significant difference after H. pylori eradication. Conclusion: This study suggests that the eradication rate of H. pylori with OCA or OMAB treatment is lower in patients with type 2 diabetes than in non-diabetics and H. pylori treatment in patients with type 2 DM has no role in the control of the glycaemia. The triple therapy (OCA) is superior to the quadruple protocol (OMAB) in H. pylori eradication of both DM and non-DM cases. © 2013 Arab Journal of Gastroenterology.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Arab J. Gastroenterol. [Field not mapped to EPrints] C2 - 23820501 [Field not mapped to EPrints] AD - Department of Internal Medicine, Qom University of Medical Sciences, Qom, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Glycaemia control, Helicobacter pylori, Treatment protocols, Type 2 diabetes mellitus, amoxicillin, bismuth citrate, clarithromycin, glucose, hemoglobin A1c, metronidazole, omeprazole, adult, article, drug efficacy, female, glucose blood level, Helicobacter infection, human, major clinical study, male, non insulin dependent diabetes mellitus, priority journal, treatment duration, urea breath test, Aged, Aged, 80 and over, Anti-Bacterial Agents, Anti-Ulcer Agents, Blood Glucose, Diabetes Mellitus, Type 2, Double-Blind Method, Drug Therapy, Combination, Female, Helicobacter Infections, Helicobacter pylori, Humans, Male, Middle Aged
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 08:58
Last Modified: 11 May 2015 05:20
URI: http://eprints.goums.ac.ir/id/eprint/1876

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