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A pooled analysis of diagnostic value of 99mTC-ubiquicidin (UBI) scintigraphy in detection of an infectious process

Assadi, M. and Ostovar, A. and Assadi, M. and Vahdat, K. and Nabipour, I. and Javadi, H. and Eftekhari, M. (2013) A pooled analysis of diagnostic value of 99mTC-ubiquicidin (UBI) scintigraphy in detection of an infectious process. Clinical Nuclear Medicine, 38 (6). pp. 413-416. ISSN 03639762 (ISSN)

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Abstract

PURPOSE: Although the data are promising from limited studies with technetium-99m ubiquicidin (Tc-UBI) scintigraphy in detection of infection in humans, these studies have had a limited sample size. This study was conducted to provide a systematic review and meta-analysis of the reported diagnostic accuracy of Tc-UBI scintigraphy in detection of an infectious process. MATERIALS AND METHODS: The PubMed/MEDLINE, Web of Science, EMBASE, and Google Scholar literature databases were systematically searched to find the relevant human studies on Tc-UBI scintigraphy. For each eligible study, the true-positive, false-positive, true-negative, and false-negative findings at Tc-UBI scintigraphy were recorded, and the overall statistical parameters were acquired. RESULT: Ten studies carried out from 2004 to 2010 were included in the analysis. The pooled data sensitivity was 94.5 % and with a 95% confidence interval of 91.2%-96.8%. The pooled specificity was still as high as about 92.7%. The range of reported specificity was from 80% to 100%. The overall accuracy was 93.7% (95% CI: 91.2%-95.7%). CONCLUSION: The study demonstrated that Tc-UBI scintigraphy can be used to identify an infectious process with admirable accuracy in early views; however, further investigations are recommended. Copyright © 2013 by Lippincott Williams & Wilkins.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Clin. Nucl. Med. [Field not mapped to EPrints] C2 - 23652406 [Field not mapped to EPrints] AD - Department of Infectious Diseases, Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GUOMS), Gorgan, Iran [Field not mapped to EPrints] AD - Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 3631, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: 99mTc-UBI scan, Antimicrobial peptides, Infection, radiopharmaceutical agent, ubiquicidin tc 99m, unclassified drug, article, diagnostic accuracy, diagnostic test accuracy study, diagnostic value, false negative result, false positive result, gold standard, human, meta analysis, scintigraphy, sensitivity and specificity, systematic review, Humans, Infection, Organotechnetium Compounds, Peptide Fragments, Radionuclide Imaging, Sensitivity and Specificity
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 03:36
Last Modified: 10 May 2015 04:16
URI: http://eprints.goums.ac.ir/id/eprint/1875

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