Golestan University of Medical Sciences Repository

Aflatoxin contamination of wheat flour and the risk of esophageal cancer in a high risk area in Iran

Ghasemi-Kebria, F. and Joshaghani, H. and Taheri, N.S. and Semnani, S. and Aarabi, M. and Salamat, F. and Roshandel, G. (2013) Aflatoxin contamination of wheat flour and the risk of esophageal cancer in a high risk area in Iran. Cancer Epidemiology, 37 (3). pp. 290-293. ISSN 18777821 (ISSN)

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Abstract

Background: Golestan province in northeastern Iran has been known as a high-risk area for esophageal cancer (EC). This study was conducted to assess aflatoxin (AF) contamination of wheat flour (WF) samples in high and low EC-risk areas of Golestan province. Methods: Four WF samples were collected randomly from each of 25 active silos throughout the province in 2009. The levels of AFs were measured using the High-performance liquid chromatography method. Using the data of EC rates obtained from Golestan population-based cancer registry, the province was divided into high and low risk areas for EC. Student t-test and multivariate regression analysis were used to compare the levels of aflatoxins as well as the condition of silos between the two areas. Results: One hundred WF samples were collected. The mean levels of total aflatoxin and aflatoxin B1 was 1.99 and 0.53ngg-1, respectively. The levels of total AF (p=0.03), AFG2 (p=0.02) and AFB1 (p=0.003) were significantly higher in samples obtained from high risk area. Multivariate regression analysis showed that humidity of silo was the most important source of difference between silos of the two areas (p=0.04). Conclusion: We found a positive relationship between AF level of WF samples and the risk of EC. So, AF contamination may be a possible risk factor for EC in our region. We also found that humidity of silos was the most important determinant of AF contamination of WF. Intensive control of silos conditions including humidity and temperature are needed especially in high EC-risk areas. © 2013 Elsevier Ltd.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Cancer Epidemiol. [Field not mapped to EPrints] C2 - 23434312 [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Young Researchers Club, Gorgan Branch, Islamic Azad University, Gorgan, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Aflatoxin, Esophageal cancer, Northeastern Iran, Wheat flour, aflatoxin, aflatoxin B1, article, cancer incidence, cancer risk, carcinogenesis, cross-sectional study, esophagus cancer, flour, food contamination, humidity, Iran, liquid chromatography, priority journal, risk assessment, wheat flour, Aflatoxins, Chromatography, High Pressure Liquid, Cross-Sectional Studies, Esophageal Neoplasms, Flour, Humans, Iran, Risk Factors, Triticum
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2015 09:28
Last Modified: 10 May 2015 04:56
URI: http://eprints.goums.ac.ir/id/eprint/1871

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