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Serum lactate as a prognostic factor in coronary artery bypass graft operation by on pump method

Jabbari, A. and Banihashem, N. and Alijanpour, E. and Vafaey, H.R. and Alereza, H. and Rabiee, S.M. (2013) Serum lactate as a prognostic factor in coronary artery bypass graft operation by on pump method. Caspian Journal of Internal Medicine, 4 (2). pp. 662-666. ISSN 20086164 (ISSN)

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Abstract

Background: Lactic acidosis in cardiac surgical patients is a manifestation of systemic inflammation and excess pro-inflammatory cytokine production. This investigation was designed to integrate basic concepts about lactate acidosis with a clinically used of serum lactate in patients under coronary artery bypass surgery (CABG) by on pump method. Methods: From August to September 2012, 15 patients scheduled for routine cardiac surgery entered to our sample and followed up two weeks. Lactate concentration in arterial blood sample was studied. Method of surgery duration of cardiopulmonary bypass, aorta cross clamp timing, hemodynamic parameters, inotrope dosage and patient outcome were documented. The data were collected and analyzed. Results: The mean age of the patients was 62±14 years. The patients with a poor outcome had significantly higher lactate levels in ABG samples (p<0.001). ABG lactate levels did not correlate with the magnitude of intra-operative bleeding or volume of packed cell transfusion (p>0.05). The PH of ABG samples did not generally correlate with the ABG lactate concentration (r=0.116, p=0.68). Increased lactate concentration was reliably associated with patient hemodynamic parameters, inotrope dosage, duration of on pump time and aorta cross clamp time. Conclusion: This study demonstrates a correlation between serum lactate levels and patient prognosis after CABG surgery by on pump method.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Caspian J. Int. Med. [Field not mapped to EPrints] AD - Department of Anesthesiology and Intensive Care, Golestan University of Medical Sciences, Golestan, Iran [Field not mapped to EPrints] AD - Department of Anesthesiology and Intensive Care, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] AD - Department of Surgery, Cardiac Surgery Branch, Babol University of Medical Sciences, Babol, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Coronary artery bypass graft, Prognosis, Serum lactate, inotropic agent, lactic acid, adult, aorta clamping, aorta cross clamp time, arterial gas, arterial pH, article, clinical article, coronary artery bypass surgery, dose response, drug use, erythrocyte concentrate, female, heart ventricle ejection, human, lactate blood level, lactic acidosis, male, on pump coronary artery bypass surgery, operation duration, operative blood loss, prognosis, surgical technique, valvuloplasty
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Apr 2015 10:18
Last Modified: 10 May 2015 06:05
URI: http://eprints.goums.ac.ir/id/eprint/1866

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