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The utility and prognostic value of dipyridamole technetium-99m sestamibi myocardial perfusion imaging SPECT in predicting perioperative cardiac events following non-cardiac surgery

Asli, I.N. and Shahoseini, R. and Azizmohammadi, Z. and Javadi, H. and Assadi, M. (2013) The utility and prognostic value of dipyridamole technetium-99m sestamibi myocardial perfusion imaging SPECT in predicting perioperative cardiac events following non-cardiac surgery. Perfusion (United Kingdom), 28 (4). pp. 333-339. ISSN 02676591 (ISSN)

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Abstract

Objective: A perioperative cardiac events is one of the most important medical concerns for both surgeons and patients. The purpose of the current study was to determine the prognostic value of myocardial perfusion imaging (MPI), using dipyridamole 99m Tc-MIBI, for the prediction of perioperative cardiac events. Materials and methods: This study included 253 patients who were candidates for non-cardiac elective surgery and underwent scanning with dipyridamole 99m Tc-MIBI. Based on normal or abnormal MPI, patients were divided into two groups and all preoperative cardiac events were recorded. Risk factors, including diabetes mellitus, dyslipidemia, hypertension, smoking and age .70 years, were compared between patients with normal and abnormal MPI and, also, in patients with or without cardiac events. Results: There were 197 patients with normal and 56 patients with abnormal MPI. In total, 14 patients had perioperative cardiac events, which included myocardial infarction (MI), hypotension, arrhythmia and death; of the 14 patients with perioperative cardiac events, 12 had abnormal and two had normal MPI. There were statistically meaningful differences between the two groups (p<0.001). Based on these findings, we determined that MPI had a sensitivity of 85.7%, a specificity of 81.6%, an accuracy of 81.8%, a positive predictive value of 21.4 % and a negative predictive value of 98.9%. Conclusion: The incidence of perioperative cardiac events is higher in patients with abnormal MPI. Dipyridamole 99m Tc-MIBI myocardial perfusion imaging can accurately detect the preoperative cardiac risk of patients undergoing major non-cardiac surgery. Based on these findings, the occurrence of perioperative cardiac events in patients with abnormal MPI should be considered, especially in the older age population (age �70). © The Author(s) 2013.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Perfusion [Field not mapped to EPrints] C2 - 23482483 [Field not mapped to EPrints] AD - Department of Nuclear Medicine, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GUOMS), Gorgan, Iran [Field not mapped to EPrints] AD - Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 3631, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: 99 Tc-MIBI scan, myocardial perfusion imaging, perioperative cardiac event, dipyridamole, methoxy isobutyl isonitrile technetium tc 99m, adult, article, cardiovascular disease, cardiovascular risk, continuous infusion, diabetes mellitus, diagnostic accuracy, dyslipidemia, female, heart muscle perfusion, human, hypertension, major clinical study, male, myocardial perfusion imaging, outcome assessment, perioperative period, prediction, priority journal, prognosis, senescence, sensitivity and specificity, single photon emission computer tomography, smoking, 99 Tc-MIBI scan, myocardial perfusion imaging, perioperative cardiac event, Aged, Dipyridamole, Female, Heart Diseases, Humans, Male, Middle Aged, Myocardial Perfusion Imaging, Myocardium, Perioperative Care, Prognosis, Risk Factors, Technetium Tc 99m Sestamibi, Tomography, Emission-Computed, Single-Photon
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 06:00
Last Modified: 10 May 2015 04:13
URI: http://eprints.goums.ac.ir/id/eprint/1864

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