Golestan University of Medical Sciences Repository

Association between pruritus and serum concentrations of parathormone, calcium and phosphorus in hemodialysis patients.

Tajbakhsh, R. and Joshaghani, H.R. and Bayzayi, F. and Haddad, M. and Qorbani, M. (2013) Association between pruritus and serum concentrations of parathormone, calcium and phosphorus in hemodialysis patients. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 24 (4). pp. 702-706. ISSN 13192442 (ISSN)

[img]
Preview
PDF - Published Version
Download (90kB) | Preview

Abstract

Chronic renal disorders have a progressive course in most cases, and finally result in end-stage renal disease (ESRD). Hemodialysis (HD) is one of the mainstays in the treatment of these patients. Disturbance in calcium (Ca) and phosphorus (P) metabolism and alteration of serum levels of parathormone (PTH) are observed in these patients. One of the most common cutaneous manifestations in patients on HD is pruritus. The aim of this study is to evaluate the association between pruritus and serum concentrations of Ca, P and PTH in patients with chronic renal disease. This analytic, descriptive, cross-sectional study was performed on 120 patients on HD at the Fifth-Azar Hospital in Gorgan, Iran, in 2010. Information related to the patients, including age, gender, pruritus, time of pruritus and duration on dialysis, was extracted from questionnaires. Serum concentrations of intact PTH, Ca and P were measured. Data were analyzed by the chi-square test and SPSS-16 software. A P-value less than 0.05 was considered statistically significant. Among the 120 study patients, 50% were male and the mean age (±SD) was 49 ± 12.3 years. Sixty percent of the patients had pruritus, of whom 33.3% had PTH levels above the normal range. Among the 40% of the patients who did not have pruritus, 39.6% had PTH levels higher than the normal levels. The mean serum Ca and P levels were 8.44 ± 1.65 mg/dL and 5.48 ± 1.81 mg/dL, respectively. The mean (±SD) Ca-P product was 55.46 ± 47.16 and the mean PTH concentration was 274.34 ± 286.53 pg/mL. No significant association was found between pruritus and age, sex, serum PTH and P levels as well as Ca-P product. However, the association between serum Ca levels and pruritus was significant (P = 0.03). Our study showed that most patients with pruritus had serum Ca levels in the abnormal range (lower or higher), and there was no significant correlation between serum iPTH level and pruritis. Thus, good control of serum Ca levels is important to reduce pruritus in these patients.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Saudi J Kidney Dis Transpl [Field not mapped to EPrints] C2 - 23816717 [Field not mapped to EPrints] AD - Department of Nephrology, Golestan University of Medical Sciences, Golestan, Iran. [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: calcium, parathyroid hormone, phosphorus, calcium, parathyroid hormone, phosphorus, adolescent, adult, aged, article, blood, cross-sectional study, female, human, male, middle aged, pruritus, renal replacement therapy, young adult, blood, pruritus, Adolescent, Adult, Aged, Calcium, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Parathyroid Hormone, Phosphorus, Pruritus, Renal Dialysis, Young Adult, Adolescent, Adult, Aged, Calcium, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Parathyroid Hormone, Phosphorus, Pruritus, Renal Dialysis, Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 20 Apr 2015 09:08
Last Modified: 11 May 2015 05:18
URI: http://eprints.goums.ac.ir/id/eprint/1858

Actions (login required)

View Item View Item