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Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level

Tabaeizadeh, M. and Haghpanah, V. and Keshtkar, A. and Semnani, S. and Roshandel, G. and Adabi, K. and Heshmat, R. and Rohani, D. and Kia, A. and Hatami, E. and Jahangirrad, A. and Nabizadeh, R. and Larijani, B. (2013) Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level. Journal of Gastric Cancer, 13 (2). pp. 106-110. ISSN 2093582X (ISSN)

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Abstract

Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune disorder in 40 recently diagnosed gastric adenocarcinoma cases versus 80 healthy controls. The participants came from a region with high gastric cancer rate but sufficient iodine supply due to salt iodination. The investigation included urine iodine level, thyroid gland clinical and ultrasonograph-ic examination, and thyroid function tests. Results: Goiter was detected more frequently in the case group (P=0.001); such a finding, however, was not true for lower than normal urine iodine levels. The free T3 mean level was significantly lower in the case group compared to the control group (P=0.005). Conclusions: The higher prevalence of goiter rather than low levels of urinary iodine in gastric adenocarcinoma cases suggests that goi-ter, perhaps due to protracted but currently adjusted iodine deficiency, is more likely to be associated with gastric adenocarcinoma com-pared to the existing iodine deficiency itself. © 2013 by The Korean Gastric Cancer Association.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - J. Gastric Cancer [Field not mapped to EPrints] AD - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Endocrinology and Metabolism Research Institute, Iran [Field not mapped to EPrints] AD - Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] AD - Department of Radiology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Oncology, Golestan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: Autoimmune diseases, Goiter, Iodine, Stomach neoplasms, Thyroid function tests, iodine, liothyronine, thyroid peroxidase antibody, thyrotropin, thyroxine, adult, article, autoimmune disease, case control study, controlled study, echography, female, goiter, human, iodine deficiency, major clinical study, male, morbidity, prevalence, radioimmunoassay, stomach adenocarcinoma, thyroid disease, thyroid function test, thyroid gland examination
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 09:18
Last Modified: 11 May 2015 04:58
URI: http://eprints.goums.ac.ir/id/eprint/1857

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