Golestan University of Medical Sciences Repository

Opium: An emerging risk factor for gastric adenocarcinoma

Shakeri, R. and Malekzadeh, R. and Etemadi, A. and Nasrollahzadeh, D. and Aghcheli, K. and Sotoudeh, M. and Islami, F. and Pourshams, A. and Pawlita, M. and Boffetta, P. and Dawsey, S.M. and Abnet, C.C. and Kamangar, F. (2013) Opium: An emerging risk factor for gastric adenocarcinoma. International Journal of Cancer, 133 (2). pp. 455-461. ISSN 00207136 (ISSN)

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Abstract

Opium use has been associated with higher risk of cancers of the esophagus, bladder, larynx, and lung; however, no previous study has examined its association with gastric cancer. There is also little information on the associations between hookah (water pipe) smoking or the chewing of tobacco products and the risk of gastric cancer. In a case-control study in Golestan Province of Iran, we enrolled 309 cases of gastric adenocarcinoma (118 noncardia, 161 cardia and 30 mixed-location adenocarcinomas) and 613 matched controls. Detailed information on long-term use of opium, tobacco products and other covariates were collected using structured and validated lifestyle and food frequency questionnaires. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were obtained using conditional logistic regression models. Opium use was associated with an increased risk of gastric adenocarcinoma, with an adjusted OR (95% CI) of 3.1 (1.9-5.1), and this increased risk was apparent for both anatomic subsites (cardia and noncardia). There was a dose-response effect, and individuals with the highest cumulative opium use had the strongest association (OR: 4.5; 95% CI: 2.3-8.5). We did not find a statistically significant association between the use of any of the tobacco products and risk of gastric adenocarcinoma, overall or by anatomic subsite. We showed, for the first time, an association between opium use and gastric adenocarcinoma. Given that opium use is a traditional practice in many parts of the world, these results are of public health significance. Copyright © 2013 UICC.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Int. J. Cancer [Field not mapped to EPrints] C2 - 23319416 [Field not mapped to EPrints] AD - Digestive Disease Research Center, Tehran University of Medical Sciences, Shariati Hospital, 1411713135 Tehran, Iran [Field not mapped to EPrints] AD - Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Bethesda, MD, United States [Field not mapped to EPrints] AD - Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden [Field not mapped to EPrints] AD - Golestan Research Center of Gastroenterology and Hepatology, Gorgan University of Medical Sciences, Gorgan, Iran [Field not mapped to EPrints] AD - Institute for Translational Epidemiology, Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, United States [Field not mapped to EPrints] AD - Genome Modifications and Carcinogenesis Division, Infection and Cancer Program, German Cancer Research Center, Heidelberg, Germany [Field not mapped to EPrints] AD - Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, MD, United States [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints]
Uncontrolled Keywords: adenocarcinoma, cardia, opium, opiate, adult, aged, article, cancer risk, cardia carcinoma, case control study, controlled study, dose response, female, food frequency questionnaire, human, human cell, Iran, lifestyle, long term exposure, major clinical study, male, priority journal, stomach adenocarcinoma, stomach carcinogenesis, structured questionnaire, tobacco, tumor localization, Adenocarcinoma, Adult, Aged, Biopsy, Cardia, Case-Control Studies, Female, Humans, Iran, Male, Middle Aged, Odds Ratio, Opium, Questionnaires, Risk Factors, Stomach Neoplasms
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Apr 2015 05:09
Last Modified: 11 May 2015 04:43
URI: http://eprints.goums.ac.ir/id/eprint/1853

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